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| | 2,4-Diiodoaniline Basic information |
| Product Name: | 2,4-Diiodoaniline | | Synonyms: | 2,4-DIIODOANILINE;2,4-Diiodobenzene;(2,4-diiodophenyl)amine;Benzenamine, 2,4-diiodo-;2,4-Diiodoaniline ISO 9001：2015 REACH | | CAS: | 533-70-0 | | MF: | C6H5I2N | | MW: | 344.92 | | EINECS: | | | Product Categories: | | | Mol File: | 533-70-0.mol |  |
| | 2,4-Diiodoaniline Chemical Properties |
| Melting point | 94-95°C | | Boiling point | 346.0±32.0 °C(Predicted) | | density | 2.7480 | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 1.74±0.10(Predicted) |
| | 2,4-Diiodoaniline Usage And Synthesis |
| Uses | 2,4-Diiodoaniline is an aromatic hydrocarbon derivative and is used as an intermediate in pharmaceutical synthesis. It is used to synthesis of 5-Iodo-2-phenyl-benzimidazole. | | Synthesis | 2,4-Diiodoaniline is generally prepared by the reactions of aniline with iodine in the presence of oxidants, with ICl vapor.
Step: Freshly distilled aniline (1mL, 11mmol) was dissolved in concentrated HCl (50 mL) and diluted with water to 0.5 L. Then KICl2 (5.2 g, 22 mmol) was added portionwise with vigorous stirring at ≈20 °C, this being followed by the gradual formation of a grayish precipitate. After completion of the reaction (3h), the precipitate was filtered off and recrystallized from benzene with addition of activated carbon. The yield of diiodoaniline was 2.14g (57%), m.p. 95 °C.
1H NMR (CDCl3), δ: 3.74 (br.s, 2 H, NH2); 6.49 (d, 1 H, C(6)H, J = 8.2 Hz); 7.36 (dd, 1 H, C(5)H, J1 = 1.0 Hz; J2 = 8.2 Hz); 7.87 (d, 1 H, C(3)H, J = 1 Hz). |
| | 2,4-Diiodoaniline Preparation Products And Raw materials |
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