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| | AG 1478 HYDROCHLORIDE Basic information |
| Product Name: | AG 1478 HYDROCHLORIDE | | Synonyms: | N-(3-CHLOROPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINANINE HYDROCHLORIDE;4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE HCL;4-(3-CHLOROANILINO)-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE;AG-1478;AG 1478 HYDROCHLORIDE;Tyrphostin AG 1478, free base >99%;NSC 693255;(3-Chlorophenyl)(6,7-dimethoxyquinazolin-4-yl)amine | | CAS: | 153436-53-4 | | MF: | C16H14ClN3O2 | | MW: | 315.75 | | EINECS: | | | Product Categories: | Inhibitors;API;Inhibitor | | Mol File: | 153436-53-4.mol |  |
| | AG 1478 HYDROCHLORIDE Chemical Properties |
| Melting point | 247 °C(dec.) | | Boiling point | 458.5±45.0 °C(Predicted) | | density | 1.337 | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | insoluble in H2O; ≥15.8 mg/mL in DMSO; ≥2.38 mg/mL in EtOH with gentle warming | | pka | 5.54±0.30(Predicted) | | form | White to light yellow solid. | | color | Light orange to Yellow to Green | | λmax | 332nm(lit.) |
| RTECS | VA0953000 | | HS Code | 29339900 |
| | AG 1478 HYDROCHLORIDE Usage And Synthesis |
| Uses | A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. | | Uses | AG 1478 Hydrochloride is an epidermal growth factor receptor tyrosine kinase inhibior (EGFR inhibtor). | | Definition | ChEBI: Tyrphostin AG 1478 is a member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. It has a role as an epidermal growth factor receptor antagonist, an antineoplastic agent, a geroprotector and an antiviral agent. It is a member of quinazolines, an aromatic ether and a member of monochlorobenzenes. | | Biological Activity | Potent and selective inhibitor of epidermal growth factor receptor kinase (IC 50 values 3 nM for EGFR and > 100 μ M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC 50 = 1 μ M). | | target | EGFR |
| | AG 1478 HYDROCHLORIDE Preparation Products And Raw materials |
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