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| | 6-Chloronicotinic acid Basic information |
| | 6-Chloronicotinic acid Chemical Properties |
| Melting point | 190 °C (dec.)(lit.) | | Boiling point | 241.15°C (rough estimate) | | density | 0.5 | | refractive index | 1.5870 (estimate) | | Fp | 192°C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | deionized water: soluble | | form | Crystalline Powder | | pka | 3.24±0.10(Predicted) | | color | Off-white to beige | | Water Solubility | Soluble in water (2 mg/ml at 20°C), ethanol, methanol, DMSO, and slightly soluble in chloroform. | | Decomposition | 192 ºC | | BRN | 115993 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChIKey | UAWMVMPAYRWUFX-UHFFFAOYSA-N | | CAS DataBase Reference | 5326-23-8(CAS DataBase Reference) | | NIST Chemistry Reference | 6-Chloronicotinic acid(5326-23-8) | | EPA Substance Registry System | 6-Chloronicotinic acid (5326-23-8) |
| | 6-Chloronicotinic acid Usage And Synthesis |
| Chemical Properties | Off-white to beige crystalline powder | | Uses | 6-Chloronicotinic acid is used as building block for different chemical synthesis. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors. | | Uses | 6-Chloropyridine-3-carboxylic acid (6-chloronicotinic acid/6-CNA) has been used to study its photolytic and photocatalytic degradation. 6-CNA is a degradation product of neonicotinoid insecticides imidacloprid and acetamiprid and is known to appear in different environmental matrices. The product has been used as a media component during the isolation of 6-CNA degrading bacterial strain from imidacloprid-exposed soil samples. | | Definition | ChEBI: 6-Chloronicotinic acid is a member of pyridines and an aromatic carboxylic acid. | | General Description | 6-Chloropyridine-3-carboxylic acid is a metabolite of the neonicotinoid pesticides, imidacloprid and acetamiprid and occurs in different environmental matrices.(3) It is widely used in agricultural crop protection, domestic insect control and environmental pest management. | | Purification Methods | Purify it by recrystallisation from hot H2O and sublime it in a vacuum. [Pechmann & Welsch Chem Ber 17 2384 1884, Herz & Murty J Org Chem 26 122 1961, Beilstein 22/2 V 177.] |
| | 6-Chloronicotinic acid Preparation Products And Raw materials |
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