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| | ENDOTHELIN 1 HUMAN, PORCINE Basic information | | Description |
| Product Name: | ENDOTHELIN 1 HUMAN, PORCINE | | Synonyms: | ET-1;ET-1, HUMAN;ET-1, HUMAN AND PORCINE;ET-1 (HUMAN, BOVINE, DOG, MOUSE, PORCINE, RAT);ET-1 (HUMAN, MOUSE, RAT, PIG, BOVINE, DOG);ET-1, HUMAN, PORCINE;ET-1 (HUMAN, PORCINE, DOG, RAT);ENDOTHELIN-I, HUMAN, PORCINE | | CAS: | 117399-94-7 | | MF: | C109H159N25O32S5 | | MW: | 2491.9 | | EINECS: | | | Product Categories: | amino;Peptide;Endothelin receptor | | Mol File: | 117399-94-7.mol |  |
| | ENDOTHELIN 1 HUMAN, PORCINE Chemical Properties |
| Boiling point | 2467.3±65.0 °C(Predicted) | | density | 1.273±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | 1% acetic acid: >1 mg/mL | | form | powder | | color | white | | Water Solubility | Soluble in water. | | Merck | 13,3610 |
| WGK Germany | 3 | | RTECS | KE9446500 | | F | 3-10 | | HS Code | 2937190000 |
| | ENDOTHELIN 1 HUMAN, PORCINE Usage And Synthesis |
| Description | Endothelin 1 (ET-1) is an active peptide with strong vasoconstriction effect isolated from the supernatant of cultured porcine aortic endothelial cells. Endothelin 1 has been shown to be present in many mammals, including humans. Although vascular endothelial cells are the main source of endothelin 1, cardiomyocytes, vascular smooth muscle cells, renal tubular epithelial cells and glial cells can all produce endothelin 1, suggesting that endothelin 1 can independently participate in the complex regulatory mechanism of various organs. | | Uses | Endothelin 1 has been used for coating wells in polystyrene ELISA plates. Potent agonist for ETA and ETB endothelia receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF. | | Biological Functions | Endothelins are a family of vasoactive peptides secreted
by endothelial cells. The three major endothelin
peptides are all composed of 21 amino acids. Endothelins
are the most potent vasoconstrictors known.
Contraction of vascular smooth muscle in response to
endothelin is associated with an increase in intracellular
calcium. Increases in endothelin levels have been reported
in patients with vasospastic, hypoxic, and ischemic
diseases.The two identified isoforms of endothelin
receptors have differing affinity for the three endothelin
peptides. Selective and nonselective endothelin receptor
antagonists are in development for potential use
in the treatment of hypertension and other disorders associated
with increased vascular resistance. | | Biochem/physiol Actions | Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF. | | storage | -20°C (desiccate) |
| | ENDOTHELIN 1 HUMAN, PORCINE Preparation Products And Raw materials |
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