DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Basic information

Product Name:	DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER
Synonyms:	DIETHYL (DIFLUOROMETHANE)PHOSPHONATE;DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER;diethyl(difluoromethyl)phosphonate;DIETHYL (DIFLUOROMETHYL)PHOSPHONATE 96%;P-DifluoroMethylphosphonic Acid Diethyl Ester;1-[difluoromethyl(ethoxy)phosphoryl]oxyethane;Phosphonic acid,P-(difluoromethyl)-, diethyl ester;uoromethanephosphonate
CAS:	1478-53-1
MF:	C5H11F2O3P
MW:	188.11
EINECS:
Product Categories:	Inhibitors;Intermediates;Phosphorylating and Phosphitylating Agents
Mol File:	1478-53-1.mol

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Chemical Properties

Boiling point	96°C 15mm
density	1.193
refractive index	n20/D 1.388(lit.)
Fp	113 °C
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Oil
color	Clear Colourless
Specific Gravity	1.193
InChIKey	VVFGLBKYBBUTRO-UHFFFAOYSA-N

Safety Information

MSDS Information

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Usage And Synthesis

Chemical Properties	Colourless Liquid
Uses	Inhibitor of bacterial phosphotriesterases and an intermediate for the synthesis of 5’-diphosphate/5’-triphosphate mimics for transcriptase and glycerol kinase inhibition.
Synthesis Reference(s)	Tetrahedron Letters, 23, p. 2323, 1982 DOI: 10.1016/S0040-4039(00)87332-3

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Preparation Products And Raw materials

Raw materials	Phosphonic acid, P-(difluoroiodomethyl)-, diethyl ester-->DIETHYL (DIFLUORO(TRIMETHYLSILYL)METHYL) -PHOSPHONATE, 96-->Bromomethylboronic acid, pinacol ester-->Diethyl bromodifluoromethanephosphonate-->2-Iodopyridine-->Difluorochloromethane-->Ethyl methacrylate-->DIETHYL PHOSPHATE-->Triethyl phosphite-->Diethyl phosphite-->Diethyl chlorophosphate-->(Difluoromethyl)trimethylsilane
Preparation Products	(DIETHOXYPHOSPHORYL)DIFLUOROACETIC ACID

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