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| | Manidipine Basic information |
| Product Name: | Manidipine | | Synonyms: | Manidipine(CV-4093);MANIDIPINE;CV-4093;FRANIDIPINE;(±)-MANIDIPINE;2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(diphenylmethyl)-1-piperazinyl)ethyl methyl ester;89226-75-5 (Di-hydrochloride);1-diphenylmethyl-4-(2-hydroxyethyl)piperazine;3-{2-[4-(diphenylMethyl)piperazin-1-yl]ethyl} 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Manidipine (Manyper) | | CAS: | 89226-50-6 | | MF: | C35H38N4O6 | | MW: | 610.7 | | EINECS: | 855-394-4 | | Product Categories: | Inhibitors;Artedil, Iperten;Dihydropyridine Class Chemicals;Intermediates & Fine Chemicals;Pharmaceuticals;Dihydropyridine | | Mol File: | 89226-50-6.mol |  |
| | Manidipine Chemical Properties |
| Melting point | 125-128°C | | Boiling point | 722.0±60.0 °C(Predicted) | | density | 1.232±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | Soluble in DMSO > 10 mM | | pka | 6.12±0.10(Predicted) | | form | Powder | | LogP | 4.135 |
| | Manidipine Usage And Synthesis |
| Description | Manidipine is a dihydropyridine L- and T-type calcium channel blocker. It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; ) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively). In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol when administered at a dose of 3 mg/kg. Formulations containing manidipine have been used in the treatment of hypertension. | | Chemical Properties | Light Yellow Crystalline Solid | | Uses | Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It | | Uses | A dihydropyridine calcium channel blocker. Antihypertensive. | | Definition | ChEBI: Manidipine is a diarylmethane. |
| | Manidipine Preparation Products And Raw materials |
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