CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL

CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL Basic information
Product Name:CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL
Synonyms:Clotrimazole EP Impurity A(USP RC A);o-chlorotriphenylmethanol;Clotrimazole EP Impurity A;ClotriMazole Related CoMpound A;Benzenemethanol, 2-chloro-α,α-diphenyl-;Clotrimazole ImpuritⅠ:(2-chlorophenyl)diphenylmethanol;Clotrimazole Impurity 1(Clotrimazole EP Impurity A);ClotriMazole IMpurity A
CAS:66774-02-5
MF:C19H15ClO
MW:294.77
EINECS:
Product Categories:Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:66774-02-5.mol
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL Structure
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL Chemical Properties
Melting point 91-92 °C(Solv: acetic acid (64-19-7))
Boiling point 144-146 °C(Press: 0.01 Torr)
density 1.216±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka12.36±0.29(Predicted)
form Solid
color White to Pale Yellow
Safety Information
HS Code 2906290000
MSDS Information
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL Usage And Synthesis
Uses(2-Chlorophenyl)diphenylmethane is a triarylmethane with antiproliferative activity. (2-Chlorophenyl)diphenylmethane is a degradation product of the antifungal agent Clotrimazole (C587400).
Uses(2-Chlorophenyl)diphenylmethane (Clotrimazole EP Impurity A) is a triarylmethane with antiproliferative activity. (2-Chlorophenyl)diphenylmethane is a degradation product of the antifungal agent Clotrimazole (C587400). Clotrimazole Related Compound A
DefinitionChEBI: TRAM-3 is an organochlorine compound.
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL Preparation Products And Raw materials
Raw materials1-Chloro-2-(dichlorophenylMethyl)benzene-->Clotrimazole-->1-Chloro-2-iodobenzene-->(2-Chlorophenyl)magnesium bromide-->Methyl 2-chlorobenzoate-->Benzophenone-->Benzene
Preparation Products(2-Chlorophenyl)phenyl-methanone
3,4,5,6-TETRACHLOROFLUORESCEIN FMOC-PHE-2-CL-TRT RESIN FMOC-TYR(2-CLTRT)-OH FMOC-GLY-2-CHLOROTRITYL RESIN 2',4',5',7'-TETRABROMO-3,4,5,6-TETRACHLOROFLUORESCEIN CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL ROSE BENGAL FMOC-L-VALINE-2-CHLOROTRITYL RESIN FMOC-ALA-2-CL-TRT RESIN FMOC-MET-2-CL-TRT RESIN 4,5,6,7-TETRACHLORO-2',4',5',7'-TETRAIODOFLUORESCEIN FMOC-D-TYR(2-CLTRT)-OH FMOC-PRO-2-CL-TRT RESIN Acid Red 92 ROSE BENGAL LACTONE FMOC-ILE-2-CL-TRT RESIN BENGALE ROSE FMOC-ASP(OTBU)-2-CHLOROTRITYL RESIN Clotrimazole Related Compound A

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