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| 1-Methylpiperazine Basic information |
| 1-Methylpiperazine Chemical Properties |
Melting point | -6 °C | Boiling point | 138 °C(lit.) | density | 0.903 g/mL at 25 °C(lit.) | vapor density | 3.5 (vs air) | vapor pressure | 12 hPa (20 °C) | refractive index | n20/D 1.466(lit.) | Fp | 108 °F | storage temp. | 2-8°C | solubility | Chloroform (Soluble), Methanol (Soluble) | pka | pK1:4.94(+2);pK2:9.09(+1) (25°C,μ=0.1) | form | Liquid | Specific Gravity | 0.903 | color | Clear | PH | 11-12 (50g/l, H2O, 20℃) | explosive limit | 1.2-9.9%(V) | Water Solubility | soluble | Sensitive | Hygroscopic | BRN | 102724 | InChIKey | PVOAHINGSUIXLS-UHFFFAOYSA-N | LogP | -0.57 at 25℃ | CAS DataBase Reference | 109-01-3(CAS DataBase Reference) | NIST Chemistry Reference | Piperazine, 1-methyl-(109-01-3) | EPA Substance Registry System | Piperazine, 1-methyl- (109-01-3) |
Hazard Codes | T,F,C,Xi | Risk Statements | 10-21-23-34-36/37/38-20/21 | Safety Statements | 16-26-36/37/39-45-36 | RIDADR | UN 2734 8/PG 2 | WGK Germany | 2 | RTECS | TM1225000 | Autoignition Temperature | 320 °C | Hazard Note | Flammable/Toxic/Corrosive/Store under nitrogen | TSCA | Yes | HazardClass | 3 | PackingGroup | III | HS Code | 29335995 | Toxicity | LD50 orally in Rabbit: 2547 mg/kg LD50 dermal Rabbit 1341 mg/kg |
| 1-Methylpiperazine Usage And Synthesis |
Chemical Properties | clear liquid | Uses | 1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP) | Uses | 1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative. | Definition | ChEBI: 1-Methylpiperazine is a N-methylpiperazine. | Hazard | Moderate fire risk. | Flammability and Explosibility | Flammable | Safety Profile | Poison by
intraperitoneal route. Moderately toxic by
inhalation, ingestion, and skin contact. A
severe skin and eye irritant. Flammable
liquid when exposed to heat or flame; can
react with oxidizing materials. To fight fire,
use alcohol foam, CO2, dry chemical. When
heated to decomposition it emits toxic
fumes of NOx. |
| 1-Methylpiperazine Preparation Products And Raw materials |
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