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| | 4-THIOURACIL Basic information |
| Product Name: | 4-THIOURACIL | | Synonyms: | 4-Thiouracil97%;4-Thiouracil 97%;2(1H)-Pyrimidinone, 3,4-dihydro-4-thioxo- (9CI);4-Thiouracil ,98%;4-Thioxo-1H-pyrimidin-2-one;2-HYDROXY-4-MERCAPTOPYRIMIDINE / 4-THIOURACIL;4-thiouracyl;4-sulfanylidene-1,2,3,4-tetrahydropyriMidin-2-one | | CAS: | 591-28-6 | | MF: | C4H4N2OS | | MW: | 128.15 | | EINECS: | | | Product Categories: | PYRIMIDINE | | Mol File: | 591-28-6.mol |  |
| | 4-THIOURACIL Chemical Properties |
| Melting point | 295 °C (dec.) (lit.) | | density | 1.368 (estimate) | | refractive index | 1.7000 (estimate) | | storage temp. | Store at -20°C | | solubility | 1 M NaOH: soluble50mg/mL | | form | Powder | | pka | 5.38±0.20(Predicted) | | color | Yellow | | CAS DataBase Reference | 591-28-6(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | WGK Germany | 3 | | HS Code | 29335990 |
| | 4-THIOURACIL Usage And Synthesis |
| Description | 4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts. It absorbs ultraviolet light >300 nm and, in the presence of oxygen, acts as an energy donor to produce singlet oxygen by triplet-triplet energy transfer. The highly reactive oxygen species then reacts readily with 4-thiouracil, leading to the production of uracil and uracil-6-sulfonate, which is fluorescent at a wavelength of ~390 nm. 4-Thiouracil is used as a T. gondii uracil phosphoribosyltransferase substrate to produce 4-thiouridine monophosphate, which can ultimately be incorporated into RNA. | | Chemical Properties | yellow powder | | Uses | 4-Thiouracil is suitable reagent employed in Schneider′s media for the embryos during RNA extraction. It may be employed as reagent for the Northwestern blotting technique. | | Uses | 4-Thiouracil is a derivative of Uracil (U801000), which is a nitrogenous base in RNA nucleic acid. 4-Thiouracil is used for tagging in cell type-specific RNA isolation from intact complex tissues. | | Synthesis Reference(s) | Synthesis, p. 256, 1987 DOI: 10.1055/s-1987-27906 |
| | 4-THIOURACIL Preparation Products And Raw materials |
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