(R)-(+)-1-(4-PYRIDYL)ETHANOL

(R)-(+)-1-(4-PYRIDYL)ETHANOL Basic information
Reaction
Product Name:(R)-(+)-1-(4-PYRIDYL)ETHANOL
Synonyms:4-[(R)-1-Hydroxyethyl]pyridine;(R)-4-(1-Hydroxyethyl)pyridine,99+%,(99+% ee);(R)-4-(1-Hydroxyethyl)pyridine(R)-(+)-1-(4-Pyridyl)ethanol;(R)-1-(pyridin-4-yl)ethanol;(1R)-1-(pyridin-4-yl)ethan-1-ol;4-PyridineMethanol, α-Methyl-, (R)-;(aR)-a-Methyl-4-PyridineMethanol;(R)-(+)-alpha-Methyl-4-pyridinemethanol 99%
CAS:27854-88-2
MF:C7H9NO
MW:123.15
EINECS:
Product Categories:Alcohols, Hydroxy Esters and Derivatives;Chiral Compounds
Mol File:27854-88-2.mol
(R)-(+)-1-(4-PYRIDYL)ETHANOL Structure
(R)-(+)-1-(4-PYRIDYL)ETHANOL Chemical Properties
Melting point 67-69 °C(lit.)
Boiling point 239.7±15.0 °C(Predicted)
density 1.082±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility soluble in Methanol
pka13.52±0.20(Predicted)
form Crystalline Powder or Needles
color White
optical activity[α]20/D +55°, c = 1 in chloroform
BRN 4306037
InChIKeyHVOAMIOKNARIMR-ZCFIWIBFSA-N
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
3-10
HS Code 29333999
MSDS Information
ProviderLanguage
SigmaAldrich English
(R)-(+)-1-(4-PYRIDYL)ETHANOL Usage And Synthesis
Reaction
  1. Used for the synthesis of chiral 1-(4-pyridinyl)ethylamines
  2. Precursor for intermediates of highly stable chiral (A)6-B Supramolecular Copolymers
Reactions of 27854-88-2
Chemical PropertiesWhite needles
Uses(1R)-1-(4-Pyridyl)ethanol is a building block reagent used in the synthesis of potent GPR119 receptor agonists used in the treatment of diabetes.
Purification MethodsPurify it by recrystallisation from pet ether. The m recorded after sublimation was 59.9-60.2o, and 55o after crystallisation from *C6H6/pet ether or pet ether/*C6H6. The (-)-di-O-benzoyl tartrate salt has m 146-148o (from EtOH). [UV, ORD: Harelli & Samori J Chem Soc Perkin Trans 2 1462 1974.] The racemate recrystallises from Et2O with m 74-76o,b 90-94o/1mm. The picrate has m 125-126o (from *C6H6). [Ferles & Attia Collect Czech Chem Commun 38 611 1973, UV, NMR: Nielson et al. J Org Chem 29 2898 1964, Beilstein 21 III/IV 522, 21/2 V 217.]
(R)-(+)-1-(4-PYRIDYL)ETHANOL Preparation Products And Raw materials
HYDROQUINIDINE 4-METHYL-2-QUINOLYL ETHER Cinchonine N-(4-Trifloromethybenzyl)cinchoninum bromide HYDROQUINIDINE HYDROCHLORIDE 1-METHYL-1-(4-PYRIDYL)ETHANOL HYDROQUINIDINE 9-PHENANTHRYL ETHER Quinidine sulfate dihydrate QUINIDINE SULFATE N-BENZYLCINCHONINIUM CHLORIDE Diphenyl(4-pyridyl)methanol MESO-ALPHA,BETA-DI(4-PYRIDYL) GLYCOL (R)-(+)-1-(4-PYRIDYL)ETHANOL QUINIDINE GLUCONATE HYDROQUINIDINE 4-CHLOROBENZOATE CINCHONINE SULFATE CINCHONINE HYDROCHLORIDE HYDROQUINIDINE Quinidine

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