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| Product Name: | E-64C | | Synonyms: | (2S,3S)-TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-3-METHYLBUTANE;(2S,3S)-L-TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-3-METHYLBUTANE;(2S,3S)-3-(((S)-1-(isopentylaMino)-4-Methyl-1-oxopentan-2-yl)carbaMoyl)oxirane-2-carboxylic acid;2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,(2S,3S)-;Loxistatin Acid (E-64C);NSC 694279;E-64c, EP 475;(1S,2S)-2-(((S)-1-(Isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)cyclopropanecarboxylic | | CAS: | 76684-89-4 | | MF: | C15H26N2O5 | | MW: | 314.38 | | EINECS: | | | Product Categories: | Pepetides;Inhibitors;peptides | | Mol File: | 76684-89-4.mol |  |
| | E-64C Chemical Properties |
| storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | ≥31.4 mg/mL in DMSO; insoluble in H2O; ≥111.8 mg/mL in EtOH | | form | White to off-white solid | | InChIKey | SCMSYZJDIQPSDI-SRVKXCTJSA-N |
| WGK Germany | 3 | | RTECS | RR0404200 | | HS Code | 29241990 |
| | E-64C Usage And Synthesis |
| Description | E-64c is an active metabolite of the protease inhibitor E-64d . E-64c inhibits the cysteine proteases cathepsin B, cathepsin H, and papain but not the serine proteases trypsin, chymotrypsin, or elastase. It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease when used at concentrations ranging from 0.1 to 1 mg/ml. E-64c reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) surface glycoprotein, also known as the spike glycoprotein, in a concentration-dependent manner. | | Uses | E-64c is a cysteine protease inhibitor used for detecting autophagy in plants. | | Definition | ChEBI: E-64c is a leucine derivative. | | target | cathepsins B |
| | E-64C Preparation Products And Raw materials |
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