ChemicalBook Product Catalog Analytical Chemistry Standard Standard Substance (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride

(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride

(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Basic information
Product Name:(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
Synonyms:cis-(+-)-2-(aminomethyl)-n,n-diethyl-1-phenylcyclopropanecarboxamidemonohydr;cis-(+-)-d;Milnacipran Hydrochloride (Subject to patent free);(1R,2S)-rel-2(Amino-methyl)-N,N-diethyl-1-phenyl-cyclopropanecarboxamide, Monohydrochloride;Dalcipran;F 2207;IXEL;(1R,2S)-REL-2-(AMINOMETHYL)-N,N-DIETHYL-1-PHENYLCYCLOPROPANECARBOXAMIDE HYDROCHLORIDE
CAS:101152-94-7
MF:C15H23ClN2O
MW:282.81
EINECS:620-477-4
Product Categories:NEGGRAM;Amines;Aromatics;Chiral Reagents;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:101152-94-7.mol
(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Structure
(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Chemical Properties
Melting point 179-1810C
Fp 9℃
storage temp. 2-8°C
solubility H2O: 19 mg/mL
form solid
color white
Merck 14,6194
CAS DataBase Reference101152-94-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,T,F
Risk Statements 22-39/23/24/25-23/24/25-11
Safety Statements 7-16-36/37-45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS GZ1014010
HazardClass 6.1
PackingGroup III
HS Code 29242990
ToxicityLD50 orally in mice: 237 mg/kg (Bonnaud)
MSDS Information
ProviderLanguage
SigmaAldrich English
(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Usage And Synthesis
Chemical PropertiesCrystalline Solid
Usesantibacterial
UsesAntidepressant. A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia.
DefinitionChEBI: Milnacipran hydrochloride is a member of acetamides.
General DescriptionMilnacipran, sold under the brand names Savella?, Ixel?, Dalcipran?, or Toledomin, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the treatment of depression. In 2009, the US Food and Drug Administration (FDA) approved milnacipran for management of the chronic pain disorder fibromyalgia, making it only the third drug approved in the US for this indication besides duloxetine and pregabalin.
Biological ActivityOrally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC 50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α 1 -adrenergic and 5-HT 2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo .
Biochem/physiol ActionsSerotonin and norepinephrine reuptake inhibitor (SNRI)
storage+4°C
(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride Preparation Products And Raw materials
Mirtazapine Flavopiridol (Alvocidib) HCl Trametinib Mianserin hydrochloride Midodrine hydrochloride Saracatinib Minocycline hydrochloride Acyclovir Selumetinib Duloxetine Bortezomib Terconazole Loteprednol etabonate cyclopropyl(phenyl)methanamine (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride 1-Phenylcyclopropane-1-carbaldehyde (Z)-2-(Aminomethyl)-N,N-diethyl-1-(p-methylphenyl)cyclopropanecarboxam ide hydrochloride MILNACIPRAN HYDROCHLORIDE
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