|
| | 3-HYDROXYFLAVONE Basic information |
| | 3-HYDROXYFLAVONE Chemical Properties |
| Melting point | 171-172 °C (lit.) | | Boiling point | 320.83°C (rough estimate) | | density | 1.2653 (rough estimate) | | refractive index | 1.5740 (estimate) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO: 1 mg/ml | | form | powder to crystal | | pka | 8.80±0.20(Predicted) | | color | White to Yellow to Green | | Water Solubility | Insoluble in water. Soluble in N,N-DMF and ethanol. | | BRN | 15789 | | InChIKey | HVQAJTFOCKOKIN-UHFFFAOYSA-N | | LogP | 3.477 (est) | | CAS DataBase Reference | 577-85-5(CAS DataBase Reference) | | EPA Substance Registry System | 4H-1-Benzopyran-4-one, 3-hydroxy-2-phenyl- (577-85-5) |
| | 3-HYDROXYFLAVONE Usage And Synthesis |
| Chemical Properties | yellow fluffy powder | | Uses | Reactant involved in:• ;Studies of photochemically-induced dioxygenase-type CO-release reactivity1• ;Phase-transfer protection and deprotection of hydroxychromones2• ;O-methylation with di-Me carbonate3Reactant involved in the synthesis of biologically active molecules including:• ;2-Chloropyridine derivatives for studies of antitumor agents and telomerase inhibitors4• ;Dihydrochromenopyrazines and chromenoquinoxalines5Involved in studies of its electrochemical properties using voltammetric methodologies6 | | Uses | 3-Hydroxyflavone is a reactant involved in studies of photochemically-induced dioxygenase-type CO-release reactivity; phase-transfer protection and deprotection of hydroxychromones; and O-methylation with di-Me carbonate. As a reactant it is involved in the synthesis of biologically active molecules including 2-chloropyridine derivatives for studies of antitumor agents and telomerase inhibitors; dihydrochromenopyrazines and chromenoquinoxalines. It is also involved in studies of its electrochemical properties using voltammetric methodologies. | | Definition | ChEBI: A monohydroxyflavone that is the 3-hydroxy derivative of flavone. | | Synthesis Reference(s) | Tetrahedron Letters, 25, p. 5561, 1984 DOI: 10.1016/S0040-4039(01)81626-9 | | Purification Methods | Recrystallise it from MeOH (m 169.5-170o), EtOH, aqueous EtOH (m 167o) or hexane. It has also been purified by repeated sublimation under high vacuum, and dried at high vacuum pumping for at least one hour [Bruker & Kelly J Phys Chem 91 2856 1987]. [Beilstein 17 H 527, 17 I 268, 17 II 498, 17 III/IV 6428.] |
| | 3-HYDROXYFLAVONE Preparation Products And Raw materials |
|
