RUSCOGENIN

RUSCOGENIN Basic information

Product Name:	RUSCOGENIN
Synonyms:	FlebopoM;HeModren;Rectolander;Ruscogenin, froM Ophiopogon japonicus;(1B,3B,25R)-SPIROST-5-ENE-1,3-DIOL;RUSCOGENIN;RUSCOGENINE;(25R)-spirost-5-ene-1-beta,3-beta-diol
CAS:	472-11-7
MF:	C27H42O4
MW:	430.63
EINECS:	207-447-2
Product Categories:	Miscellaneous Natural Products;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:	472-11-7.mol

RUSCOGENIN Chemical Properties

Melting point	198-202℃
Boiling point	563.1±50.0 °C(Predicted)
density	1.18
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka	14.56±0.70(Predicted)
form	Solid
color	White

Safety Information

Safety Statements	24/25
HS Code	29389090

MSDS Information

RUSCOGENIN Usage And Synthesis

Chemical Properties	White powder
Uses	A major steroidal sapogenin from Radix ophiopogon japonicus with robust anti-inflammatory and anti-thrombotic activities. Studies suggest that it inhibits adhesion of leukocytes to a human umbilical v ein endothelial cell line (ECV304) injured by tumor necrosis factor-α (TNF-α) in a concentration-dependent manner.
Uses	A major steroidal sapogenin from Radix ophiopogon japonicus with robust anti-inflammatory and anti-thrombotic activities. Studies suggest that it inhibits adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) injured by tumor necrosis factor-α (TNF-α) in a concentration-dependent manner.
Definition	ChEBI: Ruscogenin is a triterpenoid.
target	PGE \| TNF-α \| NF-kB \| p65 \| NO \| NOS \| COX \| ERK \| JNK \| Akt \| p38MAPK \| PKA \| cAMP \| IL Receptor

RUSCOGENIN Preparation Products And Raw materials

Raw materials	α-L-Arabinopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-, 4-(hydrogen sulfate)-->ophiopogonin B-->NEORUSCOGENIN
Preparation Products	alpha-L-Rhamnose-->D(+)-Xylose

3-(1,3-Benzodioxol-5-ylmethyl)-3,4-dihydro-5,7-dihydroxy-8-methyl-4-oxo-2H-1-benzopyran-6-carboxaldehyde Ophiopogonanone B Ophiopogonis Extract SENEGENIN Diosgenin Centella asiatica extract Ophiopogonin A AURANTIO-OBTUSIN FORSYTHIN lithospermic acid B RUSCOGENIN(PRIMARY STANDARD) OPHIOPOGONIN D S-Ruscogenin,(25S)-Ruscogenin ophiopogonin B RUSCOGENIN ruscogenin-1-yl xylopyranosyl-1-3-(glucopyranosyl-1-2)fucopyranoside NEORUSCOGENIN OPHIOPOGONIN C

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