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Vidarabine monophosphate

Vidarabine monophosphate Basic information
Product Name:Vidarabine monophosphate
Synonyms:9H-Purin-6-amine,9-(5-O-phosphono-b-D-arabinofuranosyl)-;ARA-AMP;9-BETA-D-ARABINOFURANOSYLADENINE-5'-MONOPHOSPHATE;9-BETA-D-ARABINOFURANOSYL-ADENINE-5'-MONOPHOSPHORIC ACID;9-BETA-D-ARABINOFURANOSYLADENINE MONOPHOSPHATE;9-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE;ADENINE-9-BETA-D-ARABINOFURANOSIDE-5'-MONOPHOSPHATE;ADENINE-BETA-D-ARABINOFURANOSIDE-5'-PHOSPHATE
CAS:29984-33-6
MF:C10H14N5O7P
MW:347.22
EINECS:249-990-8
Product Categories:29984-33-6
Mol File:29984-33-6.mol
Vidarabine monophosphate Structure
Vidarabine monophosphate Chemical Properties
Melting point 213 °C
Boiling point 798.5±70.0 °C(Predicted)
density 2.32±0.1 g/cm3(Predicted)
storage temp. Store at 0°C
pka1.86±0.10(Predicted)
form Powder
color White to Off-white
Water Solubility Soluble in water at 4mg/ml
Safety Information
Hazard Codes Xn,T,Xi
Risk Statements 20/22-40-23/24/25-36/37/38
Safety Statements 37/39-24/25-45-36/37/39-22-36-26
RIDADR 2811
RTECS AU6204000
HazardClass 6.1(a)
PackingGroup II
HS Code 29400090
ToxicityLD50 ipr-rat: 1700 mg/kg DRFUD4 4,547,79
MSDS Information
Vidarabine monophosphate Usage And Synthesis
DescriptionVidarabine monophosphate, chemical name: 9-(5-O-Phosphono-beta-D-arabinofuranosyl)adenine is an anti deoxyribonucleic acid virus drug. IVidarabine triphosphate directly inhibits DNA polymerase and also acts as a chain terminator in DNA replication. An adenosine monophosphate analog in which ribose is replaced by an arabinose moiety. It is the monophosphate ester of VIDARABINE with antiviral and possibly antineoplastic properties.
Chemical PropertiesCrystalline
UsesAntiviral.
UsesDisrupts viral DNA synthesis. Competitive viral DNA polymerase inhibitor. Active against herpes simplex and varicella zoster viruses in vivo.
ApplicationVidarabine monophosphate has broad-spectrum anti-virus effect and can inhibit a variety of DNA viruses. It is mainly used to treat chronic hepatitis B and other viral infections, such as herpes zoster, herpes simplex and genital herpes. It has quick effect and clear curative effect. It is a common drug for clinical anti-virus treatment.
Safety ProfileModerately toxic byintraperitoneal route. When heated to decomposition itemits very toxic fumes of POx and NOx.
Vidarabine monophosphate Preparation Products And Raw materials
PotassiuM sodiuM Dehydroandrographolide Succinate Iodixanol Acetyl hypoxanthine ADENINE-BETA-D-ARABINOFURANOSIDE 5'-MONOPHOSPHATE, DIAMMONIUM SALT, [2,8-3H]- 2'-ARAADENOSINE-5'-TRIPHOSPHATE LITHIUM SALT 2-FLUORO-6-(1,2,4-TRIAZOL-1-YL)-9-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-9H-PURINE ADENINE-ARABINOFURANOSIDE-5'-TRIPHOSPHATE, SODIUM SALT Adenine 6-BENZYLOXYAMINO-9-(5-O-DIPHENYLPHOSPHONO-BETA-D-ARABINOFURANOSYL)-2-FLUORO-9H-PURINE Vidarabine monophosphate Vidarabine Cytarabine 2-FLUOROADENINE-BETA-D-ARABINOFURANOSIDE 5'-MONOPHOSPHATE, DIAMMONIUM SALT, [8-3H]- Aniline Bis(2-ethylhexyl)amine Adenosine Fludarabine phosphate Alkaline Phosphatase
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