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| | 7-Ethoxycoumarin Basic information |
| | 7-Ethoxycoumarin Chemical Properties |
| Melting point | 88-90 °C (lit.) | | Boiling point | 265.69°C (rough estimate) | | density | 1.1803 (rough estimate) | | refractive index | 1.4260 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) | | form | Solid | | color | Off-White to Pale Brown | | Water Solubility | Soluble in hot methanol (very faint turbidity), 95% ethanol (50 mg/ml), DMF, and DMSO. Insoluble in water. | | BRN | 146200 | | LogP | 2.310 (est) | | CAS DataBase Reference | 31005-02-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 8 | | Hazard Note | Irritant | | TSCA | Yes | | HS Code | 29329990 |
| | 7-Ethoxycoumarin Usage And Synthesis |
| Chemical Properties | BEIGE CRYSTALLINE POWDER | | Uses | 7-Ethoxycoumarin is a substrate for CYP2B6 used in fluorometric assays of microsomal monooxygenase activity. | | Uses | 7-Ethoxycoumarin is commonly used for metabolism studies, including hepatocyte studies, liver perfusion techniques and cytochrome P450 studies.
7-Ethoxycoumarin has been used to study the functional activity of recombinant P450. ) It has also been used as an internal standard for in vitro S-warfarin 7-hydroxylation and high performance liquid chromatography (HPLC) analysis. | | Definition | ChEBI: 7-ethoxycoumarin is a member of the class of coumarins that is umbelliferone in which the hydroxy group at position 7 is replaced by an ethoxy group. It is an aromatic ether and a member of coumarins. It derives from an umbelliferone. | | Biochem/physiol Actions | 7-Ethoxycoumarin is a cytochrome P450 substrate. | | Metabolism | 7-Ethoxycoumarin is metabolized by many cytochrome P450 enzymes active in foreign compound metabolism and has been used as a prototypic substrate to monitor P450 (P450) activity in both hepatic and extrahepatic tissues.
The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics.
Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYP1, CYP2, and CYP3 Families |
| | 7-Ethoxycoumarin Preparation Products And Raw materials |
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