Gastrin I (rat)

Gastrin I (rat) Basic information
Product Name:Gastrin I (rat)
Synonyms:GASTRIN (RAT);GASTRIN, RAT (1-17);Gastrin I, rat, ≥97% (HPLC);PYR-ARG-PRO-PRO-MET-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2;PYR-RPPMEEEEEAYGWMDF-NH2;PGLU-ARG-PRO-PRO-MET-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-MET-ASP-PHE-NH2;5-Oxo-L-Pro-L-Arg-L-Pro-L-Pro-L-Met-L-Glu-L-Glu-L-Glu-L-Glu-L-Glu-L-Ala-L-Tyr-Gly-L-Trp-L-Met-L-Asp-L-Phe-NH2;Gastrin I heptadecapeptide【rat】
CAS:81123-06-0
MF:C94H128N22O31S2
MW:2126.28
EINECS:
Product Categories:Peptide;GastrinsIslet Stem Cell Biology;Growth Factors;Islet Stem Cell Differentiation;Neuropeptides;Peptides for Cell Biology
Mol File:81123-06-0.mol
Gastrin I (rat) Structure
Gastrin I (rat) Chemical Properties
density 1.55±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility Soluble in DMSO
form Solid
pka4.19±0.10(Predicted)
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
Gastrin I (rat) Usage And Synthesis
UsesGastrin I (rat) has been used in a study for gastrin stimulation in rats to determine the expression of histidine decarboxylase and histamine metabolism in gastric oxyntic mucosa during conditions of hypergastrinemia and carcinoid tumor. It has also been used for preabsorption of anti-gastrin antibody prior to immunohistochemical assay in rats.
General DescriptionGastrin is a pyloric antral hormone, which is a small biologically active peptide thatis synthesized as a precursor. It is found to be produced in antral G cells.
Biochem/physiol ActionsGastrin plays a crucial role in the maintenance of architecture and function of oxyntic mucosa of stomach, which is involved in the secretion of acid. It also triggers the secretion of acid into the gastric lumen. Continuous increased plasma levels of gastrin or hypergastrinemia, may be involved in gastrointestinal carcinogenesis, especially if it is accompanied with inflammation. The release of this peptide is suppressed during distention, which is a result of omatostatin and intrinsic cholinergic pathways. In rats, this peptide maintains gastric mucosal integrity through the up-regulation of cyclooxygenase-2 which is, in part, mediated by heparin-binding epidermal growth factor-like growth factor (HB-EGF).
Gastrin I (rat) Preparation Products And Raw materials
PYR-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2 GLUCAGON (1-37) (PORCINE) Gastrin I (1-14), human (TFA) GastrinⅠ H-ASP-PHE-NH2 MET-BETA-ALA Gastrin I (rat) cholecystokinin pentapeptide GASTRIN (14-17) (HUMAN) Gastrin I

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