ChemicalBook Product Catalog Chemical Reagents Organic reagents Esters Methyl ester compound METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE

METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE

METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE Basic information
Preparation
Product Name:METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE
Synonyms:Methyl 4-(bromomethyl)-3-methoxybenzonate;4-BROMOMETHYL-3-METHOXY-BENZOIC ACID METHYL ESTER;METHYL3-METHOXY-4-(BROMOMETHYL)BENZONATE;METHYL4-BROMOETHYL-3-METHOXYBENZOATE;4-Brommethyl-3-methoxybenzoesuremethylester;Methyl 4-brome methyl-3-methoxy benzoate;Methyl 4-(bromomethyl)-3-(methyloxy)benzoate;Methyl 4-(bromomethyl)-3-methoxybenzoate 98%
CAS:70264-94-7
MF:C10H11BrO3
MW:259.1
EINECS:410-310-1
Product Categories:Building Blocks;C10 to C11;Aromatic Esters;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Benzoic acid;C10 to C11;Carbonyl Compounds;Esters
Mol File:70264-94-7.mol
METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE Structure
METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE Chemical Properties
Melting point 92-94°C
Boiling point 324.2±32.0 °C(Predicted)
density 1.432
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Sparingly), Methanol (Slightly)
form powder to crystal
color White to Light yellow
CAS DataBase Reference70264-94-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,N
Risk Statements 36/37/38-50/53-43-41-38
Safety Statements 26-36/37/39-61-60
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
HazardClass IRRITANT
PackingGroup Ⅲ
HS Code 2918999090
MSDS Information
METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE Usage And Synthesis
PreparationMethyl 4-(bromomethyl)-3-methoxybenzoate is prepared by the following steps:A mixture of methyl 3-methoxy-4-methylbenzoate 37 (5 g, 27.8 mmol),  NBS (4.94 g, 27.8 mmol), and benoyl peroxide (0.0008 g, 0.003 mmol)  was refluxed in CCl4 (25 ml) for 10 hours. The reaction mixture was  allowed to cool and filtered. The residue was washed with CCl4 and the  combined filtrate concentrated in vacuo. Purification by column  chromatography over silica gel (5-10% EtOAc-pet ether) furnished a colourless solid (7.19  g).Yield : 100%
UsesMethyl 4-(Bromomethyl)-3-methoxybenzoate is an intermediate used to prepare heteroarylphenyloxoacetyl and heteroarylphenylsulfonyl benzoylpiperazine analogs of BMS 378806 as HIV entry inhibitors. It is also used to synthesize steroid 5α-reductase inhibiting acylpiperidines.
METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE Preparation Products And Raw materials
Raw materialsDimethyl sulfate-->Carbon tetrachloride-->N-Bromosuccinimide-->2,2'-Azobis(2-methylpropionitrile)-->3-Hydroxy-4-methylbenzoic acid
methyl 4-(bromomethyl)-2-methoxybenzoate 4-(BROMOMETHYL)BENZALDEHYDE METHYL-3-BROMOMETHYL-5-METHOXYBENZOATE 3-Methoxy-4-methylbenzoic acid 3-Hydroxy-4-methylbenzoic acid METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE METHYL 3-HYDROXY-4-METHYLBENZOATE 4-Bromomethylbenzoic acid Methyl 4-(bromomethyl)benzoate 1-(bromomethyl)-2-methoxybenzene 2-(BROMOMETHYL)PHENOL 3-METHOXY-4-METHYLBENZALDEHYDE 4-Methylbenzyl bromide METHYL 3-METHOXY-4-METHYLBENZOATE
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