GC376

GC376 Basic information

Product Name:	GC376
Synonyms:	GC376;GPC376;3 alpha, 7 alpha-dyhydroxy-6-ethidene- cholanic acid;Sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate;(βS)-α-Hydroxy-β-[[(2S)-4-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-2-oxo-3-pyrrolidinepropanesulfonic acid sodium salt;376;GC376 sodium;GC376 (sodium salt)
CAS:	1416992-39-6
MF:	C21H32N3NaO8S
MW:	509.55
EINECS:
Product Categories:
Mol File:	1416992-39-6.mol

GC376 Chemical Properties

storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMF: 10 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
form	A crystalline solid

Safety Information

HS Code

2933299090

MSDS Information

GC376 Usage And Synthesis

Description

GC376 is an inhibitor of the main protease M^pro (3CL^pro) in coronaviruses as well as picornaviruses. This broad-spectrum antiviral compound has been used as investigational veterinary drug for treatment of feline infectious peritonitis virus (FIPV) infections. Recent studies also showed that GC376 inhibits the main protease M^pro (3CL^pro) from SARS-CoV-2 with IC₅₀ of 0.03 μM and EC₅₀ of 3.37 μM.

Uses

GC 376 sodium is a potential small molecule inhibitor which may be able to reduce the viral load of SARS-CoV-2 3CLpro.

GC376 Preparation Products And Raw materials

Raw materials

benzyl ((2S)-4-methyl-1-oxo-1-(((2S)-1-oxo-3-(2-oxo-1l2-pyrrolidin-3-yl)propan-2-yl)-l2-azanyl)pentan-2-yl)carbamate-->Methyl L-leucinate hydrochloride

Email:[email protected] [email protected]

GC376

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