N-Carbethoxy-4-piperidone

N-Carbethoxy-4-piperidone Basic information

Product Name:	N-Carbethoxy-4-piperidone
Synonyms:	1-PIPERIDINECARBOXYLIC ACID, 4-OXO-, ETHYL ESTER;4-Oxo-1-piperidinecarboxylic acid ethyl ester;N-Carbithoxy-4-Piperidone;1-Ethoxycarbonyl-4-Piperidone N-Carbethoxy-4-Hydroxy Piperidine;N-Carbethoxypiperidone;1-ETHOXYCARBONYL-4-PIPERIDONE 97+%;N-Carbethoxy-4-Piperidone99%;N-Carbethoxy-4-piperidon
CAS:	29976-53-2
MF:	C8H13NO3
MW:	171.19
EINECS:	249-984-5
Product Categories:	Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;PHARMACEUTICAL INTERMEDIATES;Piperidines, Piperidones, Piperazines;Piperidine;Boronic Acid;Heterocyclic Compounds;(intermediate of loratadine);29976-53-2
Mol File:	29976-53-2.mol

N-Carbethoxy-4-piperidone Chemical Properties

Boiling point	95-98 °C (1 mmHg)
density	1.135 g/mL at 25 °C (lit.)
vapor pressure	0.2-0.37Pa at 20-25℃
refractive index	n20/D 1.475(lit.)
Fp	190 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	-1.59±0.20(Predicted)
form	Liquid
color	Clear colorless to pale yellow
PH	4.6 (H2O, 20℃)(saturated solution)
Water Solubility	slightly soluble
BRN	640967
InChIKey	LUBGFMZTGFXIIN-UHFFFAOYSA-N
LogP	0 at 20℃ and pH6.5-6.7
CAS DataBase Reference	29976-53-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	36/38-22-36/37/38-20/21/22
Safety Statements	23-24/25-37/39-26-36
WGK Germany	3
HazardClass	IRRITANT
HS Code	29333999

MSDS Information

Provider	Language
N-Carbethoxy-4-piperidone	English
SigmaAldrich	English
ACROS	English
ALFA	English

N-Carbethoxy-4-piperidone Usage And Synthesis

Chemical Properties	clear colorless to pale yellow colored liquid
Uses	N-Carbethoxy-4-piperidone (Loratadine EP Impurity H) is used in the preparation of 3-hydrazinopyridazines as antihypertensive agents as well as γ-carboline derivatives as potential serotonergic agents. It is also an impurity of Loratadine (L469575).
Uses	Ethyl 4-oxo-1-piperidinecarboxylate (1-carbethoxy-4-piperidone) was used to prepare tertiary alcohols.

N-Carbethoxy-4-piperidone Preparation Products And Raw materials

Raw materials

Penfluridol

Preparation Products

4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE-->N-phenylpiperidin-4-amine-->4-(4-FLUORO-PHENYL)-PIPERIDIN-4-OL HYDROCHLORIDE-->Ethyl 4-amino-1-piperidinecarboxylate-->AKOS USSH-4110751-->1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-methoxy-, ethyl ester-->ethyl 4-hydroxy-4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate-->1-Piperidinecarboxylicacid,4-amino-4-cyano-,ethylester(9CI)-->ETHYL 2-AMINO-3-CARBAMOYL-4,7-DIHYDRO-5H-THIENO[2,3-C]-PYRIDINE-6-CARBOXYLATE-->ethyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate-->ethyl 4-(2,3-difluoro-6-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-4-hydroxypiperidine-1-carboxylate-->Ethyl 4-hydroxypiperidine-1-carboxylate

1-(Benzyloxycarbonyl)-4-piperidinone N-Carbethoxy-4-tropinone N-Boc-Nortropinone SALOR-INT L155756-1EA 1-FMOC-4-PIPERIDONE SALOR-INT L155764-1EA Carbethoxy N-Carbethoxy-3-methoxy-4-piperidone Ethylparaben N-BOC-3-CARBETHOXY-4-PIPERIDONE SALOR-INT L155772-1EA CIS-2-HYDROXY-1-CYCLOPENTANECARBOXYLIC ACID,99% SALOR-INT L155748-1EA Ethyl acrylate 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 1-N-ALLOC-4-PIPERIDONE RESMETHRIN FMOC-L-HOMOPRO(4-OXO)

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