ChemicalBook Product Catalog API Synthetic Anti-infective Drugs Antiviral drugs 2'-Deoxy-L-thymidine

2'-Deoxy-L-thymidine

2'-Deoxy-L-thymidine Basic information
Product Name:2'-Deoxy-L-thymidine
Synonyms:BETA-L-THYMIDINE;2'-DEOXY-L-THYMIDINE;L-Thymidine(Telbivudine);1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione;Β-L-2'-DEOXY-THYMIDINE;2'-Deoxy-L-thyMidine(Telbivudine);Telbivudine(Tyzeka, Sebivo);1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-Methyl-
CAS:3424-98-4
MF:C10H14N2O5
MW:242.23
EINECS:608-961-3
Product Categories:Anti-virals;Bases & Related Reagents;Carbohydrates & Derivatives;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;API intermediates;Amines;API;Chiral Reagents;Heterocycles
Mol File:3424-98-4.mol
2'-Deoxy-L-thymidine Structure
2'-Deoxy-L-thymidine Chemical Properties
Melting point 188-190°C
alpha D20 -20.3° (c = 0.192 in water)
density 1.452±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility H2O: soluble10mg/mL (clear solution)
pka9.55±0.10(Predicted)
form powder
color white to beige
optical activity[α]/D -15 to -22°, c = 1 in H2O
InChIKeyIQFYYKKMVGJFEH-CSMHCCOUSA-N
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 24/25
WGK Germany 3
RTECS UV9048500
HS Code 29349990
MSDS Information
2'-Deoxy-L-thymidine Usage And Synthesis
DescriptionTelbivudine is a b-L-thymidine nucleoside analog launched for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection. It is the fourth nucleoside or nucleotide analog to be marketed for this indication. The previous drugs from this class include lamivudine, a deoxythiacytosine analog, adefovir, a nucleotide analog, and entecavir, a guanosine analog. Adefovir, entecavir, and telbivudine are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections. Telbivudine is efficiently phosphorylated by cellular kinases to the active triphosphate derivative, which inhibits HBV DNA polymerase by competing with the natural substrate, thymidine- 5’-triphosphate.
Chemical Properties2'-Deoxy-L-thymidine is White Solid
OriginatorIdenix (US)
UsesNucleoside analog; specific inhibitor of hepatitis B virus (HBV) replication. Antiviral.
UsesTelbivudine(Tyzeka, Sebivo) is an antiviral drug used in the treatment of hepatitis B infection. Clinical trials have shown it to be significantly more effective than lamivudine or adefovir, and less likely to cause resistance. Telbivudine is a synthetic
DefinitionChEBI: A pyrimidine 2'-deoxyribonucleoside that is the L-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase.
Brand name(Novirio).
2'-Deoxy-L-thymidine Preparation Products And Raw materials
5'-AZIDO-5'-DEOXY-D-THYMIDINE L-THYMIDINE, [2-14C]- DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* Clevudine 3'-Azido-3'-deoxy-D-thymidine Deoxynucleotide 3'-Azido-3'-deoxy-D-thymidine-methyl-D3-2,3,4-tri-O-acetyl-b-D-glucuronidemethylester 5-METHYL-1-(β-L-RIBOFURANOSYL)URACIL 2'-Deoxy-L-thymidine-d3 BETA-L-THYMINE RIBOSIDE, [METHYL-3H]- 3'-Deoxy-D-thymidine 2'-Deoxy-L-thymidine 2'-DEOXY-L-THYMIDINE-5'-TRIPHOSPHATE LITHIUM SALT Deoxidizer Thymidine 1-(2'-FLUORO-2'-DEOXY-BETA-L-ARABINOFURANOSYL)-5-METHYLURACIL, [5-3H]- 5-METHYL-1-(2'', 3'', 5''-TRI-O-BENZOYL-β-L-RIBOFURANOSYL)URACIL CHLOROPHOSPHONAZO III
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