ChemicalBook Product Catalog API Synthetic Anti-infective Drugs Antifungal Drugs BAFILOMYCIN B1

BAFILOMYCIN B1

BAFILOMYCIN B1 Basic information
Product Name:BAFILOMYCIN B1
Synonyms:BAFILOMYCIN B1;BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO- MYCES SPECIES;BafilomycinB1fromStreptomycesgriseus;bafilomycin b1from streptomyces sp.;hygrolidin,37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclopenten-1-yl)am;ino)carbonyl)-2-methoxy-24-methyl-;37-De(carboxy)-2-demethyl-37-[[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]carbonyl]-2-methoxy-24-methylhygrolidin;2-Butenoic acid, 4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-, (2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethy...
CAS:88899-56-3
MF:C44H65NO13
MW:815.99
EINECS:
Product Categories:Antibiotic;MacrolidesMore...Close...;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Antibiotics by Application;AntifungalAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Chemical Structure Class;Inhibits an EnzymeAntibiotics;Mechanism of Action;Spectrum of Activity
Mol File:88899-56-3.mol
BAFILOMYCIN B1 Structure
BAFILOMYCIN B1 Chemical Properties
storage temp. −20°C
solubility DMSO: Soluble; Methanol: Unstable
form powder or crystals
color faint yellow to yellow
BRN 4640118
Stability:Hygroscopic
Safety Information
Hazard Codes T+
Risk Statements 26/27/28
Safety Statements 36/37/39-45
RIDADR UN 3462 6.1/PG 1
WGK Germany 3
RTECS NG8841000
F 10-21
HazardClass 3
HS Code 2941900000
MSDS Information
BAFILOMYCIN B1 Usage And Synthesis
DescriptionBafilomycin B1 is a fungal metabolite that has been found in Streptomyces and has diverse biological activities. It inhibits the activity of rat liver lysosomal vacuolar H+-ATPase (V-ATPase) in a concentration-dependent manner. Bafilomycin B1 (10-1,000 nM) induces autophagosome accumulation in MCF-7 cells. It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) when used at a concentration of 1 nM. Bafilomycin B1 reduces viral genome copy numbers in the culture supernatant of Vero E6 cells infected with H1N1 influenza A.
UsesBafilomycin B1 is a member of a potent family of macrocyclic lactones. Bafilomycin B1 shares the same mode of action and activity as its more accessible A1 analogue. Bafilomycin B1 is broadly active against bacteria, fungi, insects, nematodes and protozoans. Bafilomycin B1 has attracted interest as a potential agent for treating osteoporosis.
BAFILOMYCIN B1 Preparation Products And Raw materials
B-1 Doxycycline Bafilomycin D1 Bafilomycin D2' BAFILOMYCIN C1 bafilomycin D BAFILOMYCIN B2 BAFILOMYCIN B2 FROM STREPTOMYCES GRISEUS Bafilomycin A1 from Streptomycesgriseus, 10 ug,BAFILOMYCIN A1, 98+%,BAFILOMYCIN A1 95%,BAFILOMYCIN A1, STREPTOMYCES GRISEUS,BAFILOMYCIN A1 BAFILOMYCIN B1 MONOHYDRATE Bafilomycin C2 Bafilomycin A2 Bafilomycin E BAFILOMYCIN A1 (DRY ICE)
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