2-Amino-3-picoline

2-Amino-3-picoline Basic information
Product Name:2-Amino-3-picoline
Synonyms:AURORA KA-876;2-AMINO-3-PICOLINE 96%;2-amino-3-methyl-pyridin;2-Amino-beta-picoline;2-Pyridinamine,3-methyl-;3-Methyl-2-aminopyridine;3-methyl-2-pyridinamin;3-Methyl-2-pyridinamine
CAS:1603-40-3
MF:C6H8N2
MW:108.14
EINECS:216-501-4
Product Categories:amine;Pyridine;VARIOUSAMINE;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Pyridines derivates;bc0001
Mol File:1603-40-3.mol
2-Amino-3-picoline Structure
2-Amino-3-picoline Chemical Properties
Melting point 29-31 °C (lit.)
Boiling point 221-222 °C (lit.)
density 1.073 g/mL at 25 °C (lit.)
refractive index n20/D 1.5823(lit.)
Fp 233 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility 1000g/l
form Liquid After Melting
pkapK1: 7.24(+1) (25°C)
color Clear yellow
Water Solubility SOLUBLE
Sensitive Hygroscopic
BRN 107892
InChIKeyRGDQRXPEZUNWHX-UHFFFAOYSA-N
CAS DataBase Reference1603-40-3(CAS DataBase Reference)
NIST Chemistry Reference2-Pyridinamine, 3-methyl-(1603-40-3)
EPA Substance Registry System2-Pyridinamine, 3-methyl- (1603-40-3)
Safety Information
Hazard Codes T
Risk Statements 23/24/25-33-36/37/38-25
Safety Statements 36/37/39-45-37/39-28A-26
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS US1850000
TSCA Yes
HazardClass 6.1
PackingGroup II
HS Code 29333999
MSDS Information
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2-Amino-3-picoline Usage And Synthesis
Chemical Properties2-Amino-3-picoline is CLEAR YELLOW LIQUID AFTER MELTING
Uses2-Amino-3-picoline is used in the synthesis of ketones from aldehydes.
Synthesis Reference(s)Journal of the American Chemical Society, 95, p. 4453, 1973 DOI: 10.1021/ja00794a070
HazardToxic by ingestion.
Purification MethodsRecrystallise the picoline three times from *benzene, most of the residual *benzene being removed from the crystals by standing over paraffin wax chips in an evacuated desiccator. The amine is also transferred to a separating funnel under N2, and left in contact with NaOH pellets for 3hours with occasional shaking. It is then placed in a vacuum distilling flask where it is refluxed gently in a stream of dry N2 before fractionally distilling it. [Mod et al. J Phys Chem 60 1651 1956, Beilstein 22/9 V 212].
2-Amino-3-picoline Preparation Products And Raw materials
Preparation Products2-AMINO-4-METHOXYPYRIDINE-3-CARBOXYLIC ACID-->5-Amino-2-chloro-3-picoline-->4-METHOXY-3-METHYLPYRIDIN-2-AMINE-->2-Chloro-5-cyano-3-methylpyridine-->2-(2,2,2-TRIFLUOROETHOXY)PYRIDINE-3-CARBOXYLIC ACID-->2-CHLORO-4-METHOXY-3-METHYLPYRIDINE-->1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL--->2-CHLORO-3-METHYL-4-METHOXYPYRIDINE N-OXIDE-->2-Amino-5-hydroxypyridine-->2-CHLORO-5-IODO-3-METHYLPYRIDINE-->2-CHLORO-3-METHYL-4-NITROPYRIDINE N-OXIDE-->2-ACETAMIDOPYRIDINE-3-CARBOXYLIC ACID-->2-BROMO-3-METHYLPYRIDINE-5-BORONIC ACID-->2-(Trifluoromethyl)nicotinic acid-->2-Bromo-3-methylpyridine-->2-NITRONICOTINIC ACID-->2-CHLORO-3-METHYLPYRIDINE-5-BORONIC ACID-->2-Amino-5-bromo-3-methylpyridine-->3-Methyl-2-nitropyridine-->6-AMINO-5-METHYLNICOTINONITRILE-->2,5-DIBROMONICOTINALDEHYDE-->2-Amino-3-methyl-5-nitropyridine-->FMOC-2-AMINONICOTINIC ACID-->2-AMINO-5-NITROPYRIDINE-3-CARBOXYLIC ACID-->(2-Aminopyridin-3-yl)methanol-->2-AMINO-5-CHLORO-3-PICOLINE-->2-HYDROXY-3-METHYL-5-NITROPYRIDINE-->Ethyl 2-aminopyridine-3-carboxylate-->2-Chloro-3-methyl-5-bromopyridine-->PEMIROLAST-->2-ACETAMIDO-3-PICOLINE-->6-AMINO-5-METHYLPYRIDINE-3-SULFONIC ACID
2,6-Diaminopyridine 2-AMINO-5-PICOLINE,2-AMINO-5-METHYLPYRIDINE (2-AMINO-5-PICOLINE),6-AMINO-3-PICOLINE,6-AMINO-BETA-PICOLINE 2-Amino-4,6-dimethylpyridine 4-Methylpyridine 6-AMINO-2-PICOLINE,2-AMINO-6-PICOLINE,2-Amino-6-picoline ,98%,2-AMINO-6-METHYLPYRIDINE (2-AMINO-6-PICOLINE),6-AMINO-ALPHA-PICOLINE ALTRENOGEST 2-Amino-3-picoline DIMETHYLAMINOPYRIDINE, POLYMER-BOUND 3-Aminopyridine 6-Aminocaproic acid Glycine 3-Picoline 2-Aminopyridine Tris(hydroxymethyl)aminomethane AMINO ACIDS 3-Aminophenol 4-Aminopyridine 2-AMINO-4-PICOLINE

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