(S)-3-Hydroxypyrrolidine hydrochloride

(S)-3-Hydroxypyrrolidine hydrochloride Basic information

Product Name:	(S)-3-Hydroxypyrrolidine hydrochloride
Synonyms:	(S)-PYRROLIDIN-3-OL HCL;(S)-PYRROLIDINE-3-OL HYDROCHLORIDE;TIMTEC-BB SBB004272;(S)-3-HYDROXY PYRROLIDINE HCL;(S)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE;(S)-(-)-3-PYRROLIDINOL HYDROCHLORIDE;(S)-3-PYRROLIDINOL HYDROCHLORIDE;3-PYRROLIDINOL, HYDROCHLORIDE, (3S)
CAS:	122536-94-1
MF:	C4H10ClNO
MW:	123.58
EINECS:	672-315-7
Product Categories:	Chiral chemicals;Benzenes;pharmacetical;Pyrrole&Pyrrolidine&Pyrroline;chiral;Heterocyclic Compounds;Alcohols and Derivatives;Intermediate
Mol File:	122536-94-1.mol

(S)-3-Hydroxypyrrolidine hydrochloride Chemical Properties

Melting point	104-107°C
Boiling point	108-110℃/8mm
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Sparingly), Methanol (Slightly)
form	Solid
color	Off-White to Pale Beige
Stability:	Hygroscopic
CAS DataBase Reference	122536-94-1(CAS DataBase Reference)

Safety Information

MSDS Information

(S)-3-Hydroxypyrrolidine hydrochloride Usage And Synthesis

Chemical Properties	almost white crystalline powder
Uses	(S)-3-Hydroxypyrrolidine Hydrochloride is a useful intermediate for the synthesis of Asimadoline Hydrochlorine (A788250), used in the treatment of IBS, a disorder associated with pain and altered bowel function.

(S)-3-Hydroxypyrrolidine hydrochloride Preparation Products And Raw materials

Raw materials	Ethanol-->Sodium hydroxide-->Hydrochloric acid-->Ethyl acetate-->Methanol-->Tetrahydrofuran-->Dichloromethane-->Acetic acid-->PETROLEUM ETHER-->Lithium Aluminum Hydride-->Sodium borohydride-->Acetyl chloride-->Calcium chloride-->Benzylamine-->HEAVY DISTILLATE-->L-Malic acid
Preparation Products	LOXO-101 (sulfate)

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