ChemicalBook Product Catalog Chemical Reagents Organic reagents Boric acid 4-Trifluoromethoxyphenylboronic acid

4-Trifluoromethoxyphenylboronic acid

4-Trifluoromethoxyphenylboronic acid Basic information
Product Name:4-Trifluoromethoxyphenylboronic acid
Synonyms:AKOS BRN-0136;4-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID;4-(TRIFLUOROMETHOXY)BENZENEBORONIC ACID;P-TRIFLUOROMETHOXY BENZOBORIC ACID;P-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID;RARECHEM AH PB 0078;4-(Trifluoromethoxy)phenylboronicAcid(containsvaryingamountsofAnhydride);4-Trifluoromethoxyphenylboronic acid 4-(Trifluoromethoxy)benzeneboronic acid
CAS:139301-27-2
MF:C7H6BF3O3
MW:205.93
EINECS:000-000-0
Product Categories:Aryl;Fluorinated;Organoborons;B (Classes of Boron Compounds);Boronic Acids;Building Blocks for Liquid Crystals;Substituted Boronic Acids;Boronic Acid;Chalcones, etc. (Building Blocks for Liquid Crystals);Functional Materials;Boronic Acids;Boronic Acids and Derivatives;Boronate Ester;Potassium Trifluoroborate;blocks;BoronicAcids;FluoroCompounds;Boronic Acid series;bc0001
Mol File:139301-27-2.mol
4-Trifluoromethoxyphenylboronic acid Structure
4-Trifluoromethoxyphenylboronic acid Chemical Properties
Melting point 123-127 °C(lit.)
Boiling point 256.6±50.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
pka8.29±0.10(Predicted)
form Crystalline Powder
color White to beige
BRN 8548201
InChIKeyHUOFUOCSQCYFPW-UHFFFAOYSA-N
CAS DataBase Reference139301-27-2(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-20/21/22
Safety Statements 37/39-26-36
WGK Germany 3
Hazard Note Irritant
HS Code 29319090
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
4-Trifluoromethoxyphenylboronic acid Usage And Synthesis
Chemical Propertieswhite to beige crystalline powder
UsesB-[4-(Trifluoromethoxy)phenyl]boronic Acid is a reagent used in the synthesis of orally bioavailable matrix metalloprotinase inhibitors. Also used in the preparation of chromen-4-one inhibitors used against DNA dependant protein kinases.
Application4-Trifluoromethoxyphenylboronic acid can reactant involved in the synthesis of biologically active molecules including:
Lactate dehydrogenase inhibitors for use against cancer cell proliferation
Nitro-phenoxybenzoic acid derivatives for PAI-1 inhibition
PA-824 analogs for use as antituberculosis drugs
Modulators of survival motor neuron protein
Reactant involved in addition reactions and cross-coupling reactions including Suzuki-Miyaura cross-coupling
4-Trifluoromethoxyphenylboronic acid Preparation Products And Raw materials
Preparation ProductsNVP-LDE225-->6-[4-(TrifluoroMethoxy)phenyl]-3-pyridinecarbaldehyde-->5-Bromo-2-[4-(trifluoromethoxy)phenyl]pyridine-->5-(4-Trifluoromethoxyphenyl)-picolinic acid-->5-[4-(TrifluoroMethoxy)phenyl]furan-2-carboxylic Acid-->4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester
4-(Trifluoromethoxy)benzaldehyde 4'-Methoxyacetophenone 4-Methoxybenzyl cyanide p-Trifluoromethoxy phenol 4-Methoxybenzyl alcohol 4-(Trifluoromethoxy)aniline 4-Trifluoromethoxyphenylboronic acid 4'-(Trifluoromethoxy)acetophenone Anisole (Trifluoromethoxy)benzene (4-METHOXYPHENYL)-BORANE p-Anisic acid 4-Trifluoromethylphenylboronic acid 2-(Trifluoromethoxy)aniline p-Anisaldehyde 4-Methoxybenzoyl chloride 4-(Trifluoromethoxy)chlorobenzene 2-CHLORO-4-TRIFLUOROMETHOXYBENZENEBORONIC ACID
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