4-Biphenylcarbonyl chloride

4-Biphenylcarbonyl chloride Basic information

Product Name:	4-Biphenylcarbonyl chloride
Synonyms:	Biphenyl-4-carbonylchloride98%;P-PHENYLBENZOYL CHLORIDE;4-PHENYLBENZOYL CHLORIDE;4-BIPHENYLCARBONYL CHLORIDE;4-BIPHENYLCARBONYL CHLORIDE CRYSTALLINE;Biphenyl-4-carbonyl chloride 98%;BIPHENYL-4-CARBONYL CHLORIDE;[1,1’-biphenyl]-4-carbonylchloride
CAS:	14002-51-8
MF:	C13H9ClO
MW:	216.66
EINECS:	237-804-8
Product Categories:	Biphenyl derivatives;Absolute Configuration Determination (Exciton Chirality CD Method);Analytical Chemistry;Enantiomer Excess & Absolute Configuration Determination;Exciton Chirality CD Method (for Hydroxyl Groups)
Mol File:	14002-51-8.mol

4-Biphenylcarbonyl chloride Chemical Properties

Melting point	110-112 °C (lit.)
Boiling point	160 °C / 2mmHg
density	1.1459 (rough estimate)
refractive index	1.5260 (estimate)
storage temp.	Inert atmosphere,Room Temperature
form	Fine Crystalline Powder
color	White to yellow
Water Solubility	HYDROLYSIS
Sensitive	Moisture Sensitive/Lachrymatory
BRN	472842
InChIKey	JPVUWCPKMYXOKW-UHFFFAOYSA-N
CAS DataBase Reference	14002-51-8(CAS DataBase Reference)
EPA Substance Registry System	[1,1'-Biphenyl]-4-carbonyl chloride (14002-51-8)

Safety Information

Hazard Codes	C
Risk Statements	14-34
Safety Statements	26-36/37/39-43-45-25
RIDADR	UN 3261 8/PG 2
WGK Germany	3
F	21-10
Hazard Note	Corrosive/Lachrymatory/Moisture Sensitive
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29163990

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

4-Biphenylcarbonyl chloride Usage And Synthesis

Chemical Properties	4-Biphenylcarbonyl chloride is white to yellow fine crystalline powder
Uses	Biphenyl-4-carbonyl chloride was used in the preparation of a novel thiourea compound, N-(6-methyl pyridin-2-yl-carbamothioyl)biphenyl-4-carboxamide. It was also used in the preparation of 5-CF3-oxazole analog, 2-{4-[2-(2-biphenyl-4-yl-5-trifluoromethyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid.
Purification Methods	Dissolve the carbonyl chloride in a large volume of pet ether (10 x, b 50-70o), filter it through a short column of neutral alumina, evaporate to dryness in vacuo and recrystallise it from pet ether (b 60-80o). [Beilstein 9 IV 2480.] LACHRYMATORY.

4-Biphenylcarbonyl chloride Preparation Products And Raw materials

Raw materials	Dichloromethane-->Thionyl chloride-->Oxalyl chloride-->4-Biphenylcarboxylic acid-->4-Biphenylcarboxaldehyde-->Methyl 4-phenylbenzoate-->4-Biphenylmethanol-->2-(4,5-Dihydrooxazol-2-yl)aniline-->4-Phenyltoluene-->carbon monoxide-->Methyl 4-bromobenzoate-->4-Iodobiphenyl-->4-Acetylbiphenyl-->Butyryl chloride-->Biphenyl-->4-Bromobiphenyl
Preparation Products	4,4'-DIPHENYLBENZOPHENONE-->Fenbufen

Biphenyl-4,4'-dithiol DIETHYL BIPHENYL-4,4'-DICARBOXYLATE Methyl 4-phenylbenzoate 2,3,4,5-Tetrafluorobenzoyl chloride 4-Methylbenzyl chloride 4-Nitrobenzoyl chloride 4'-CHLOROBIPHENYL-4-CARBONYL CHLORIDE p-Tolualdehyde 4-Biphenylcarbonyl chloride o-Toluoyl chloride Methylaminoformyl chloride 4,4'-BIPHENYLDICARBONYL CHLORIDE 4'-ETHYL-BIPHENYL-4-CARBONYL CHLORIDE 4-Phenyltoluene 4-Chlorobenzoyl chloride Thionyl chloride 4-(Chloromethyl)biphenyl 2-[[(2-ethylphenyl)(2-hydroxyethyl)amino]methyl]-3,3-difluoro-Propanenitrile

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