ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Basic information
Product Name:4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester
Synonyms:fg-4592 int 2;1 - methyl - 4 - hydroxy - 7 - phenoxy isoquinoline - 3 - methyl formate;4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester;Fg-4592/FG4592 int 2;ROXA-019;methyl 4-hydroxy-1-methyl-7-pheno1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid xyisoquinoline-3-carboxylate;3-Isoquinolinecarboxylic acid, 4-hydroxy-1-methyl-7-phenoxy-, methyl ester;4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid
CAS:1421312-34-6
MF:C18H15NO4
MW:309.32
EINECS:
Product Categories:API
Mol File:1421312-34-6.mol
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Structure
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Chemical Properties
Boiling point 537.3±45.0 °C(Predicted)
density 1.289±0.06 g/cm3(Predicted)
pka6.24±0.50(Predicted)
Safety Information
MSDS Information
4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Usage And Synthesis
Uses4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid is used as a reagent in the preparation of Roxadustat (H948180), which is a drug used to treat anemia and chronic renal insufficiency.
PreparationAdd 25 g of glacial acetic acid solution containing methyl 1-((dimethylamino)methyl)-4-hydroxy-7-phenoxyisoquinolyl-3-carboxylate into a 1 L four-necked flask which contain 13 g Zinc powder. Then in a stirring state, add 7.5g of 5% dilute hydrochloric acid and raise the temperature to 50-60 ℃. When the raw materials in the liquid phase have basically reacted, reduce the temperature. Filter reaction solution.  Rotary evaporated the filtrate obtain 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester (purity: 96.9%, yield: 87.7%).
FG-4592 interMediate 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid ethyl ester Roxadustat
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