ChemicalBook Product Catalog Organic Chemistry Hydrocarbons and derivatives 4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide

4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide

4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide Basic information
Product Name:4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide
Synonyms:4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide;SW155246;Benzenesulfonamide, 4-chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-;SW155246 >=98% (HPLC);4-chloro-N-(4-hydroxynaphthalen- 1-yl)-3-nitrobenzenesulfonamide;SW 155246,cancer,hDNMT1,DNMTs,DNMT1 inhibitor,SW155246,Inhibitor,SW-155246,inhibit,mDNMT3A,DNA MTases,DNA Methyltransferase
CAS:420092-79-1
MF:C16H11ClN2O5S
MW:378.79
EINECS:
Product Categories:
Mol File:420092-79-1.mol
4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide Structure
4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide Chemical Properties
storage temp. 2-8°C
solubility DMSO: soluble10mg/mL, clear
form powder
color white to light brown
Safety Information
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
MSDS Information
4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide Usage And Synthesis
DescriptionSW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1; IC50 = 1.2 μM). It is selective for human DNMT1 over murine DNMT3 (IC50 = 38 μM). SW155246 inhibits HeLa and A549 tumor cell growth in a redox-independent manner (IC50s = 8-20 μM). It also inhibits genomic methylation in HeLa cells when used at concentrations ranging from 10 to 18.6 μM.
4-Chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide Preparation Products And Raw materials
SW076956 2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[5,4-b]pyridin-3-amine 2-(5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide
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