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| | Cefoselis sulfate Basic information |
| Product Name: | Cefoselis sulfate | | Synonyms: | CEFOSELIS SULFATE;FK 037;7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-[[2-(2-hydroxyethyl)-3-imino-1-pyrazolyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sulfate;Winsef;(6R,7R,E)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((2-(2-hydroxyethyl)-3-imino-2,3-dihydropyrazol-1-yl)methyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid, sulfate;FK 037 Sulfate;Cefoselis sulfate USP/EP/BP | | CAS: | 122841-12-7 | | MF: | C19H24N8O10S3 | | MW: | 620.63 | | EINECS: | 1533716-785-6 | | Product Categories: | Inhibitors;Cefoselis sulfate and its intermediates | | Mol File: | 122841-12-7.mol |  |
| | Cefoselis sulfate Chemical Properties |
| storage temp. | 4°C, protect from light, stored under nitrogen | | solubility | DMSO : 100 mg/mL (161.12 mM; Need ultrasonic)H2O : 14.29 mg/mL (23.02 mM; Need ultrasonic) | | form | Powder | | CAS DataBase Reference | 122841-12-7(CAS DataBase Reference) |
| | Cefoselis sulfate Usage And Synthesis |
| Description | Cefoselis is a new fourth-generation cephalosporin and was launched
in Japan as a parenteral antibiotic for a variety of infections including
Staphylococcus aureus (particularly the methicillin-resistant MRSA) and
Pseudornonas aeruginosa. It can be prepared in 3 related ways, all using 2-
pyrazolomethyl-3-cephem-4-carboxylic as the key intermediate. In preclinical
studies, Cefolesis had better MIC50s than Ceftazidime against Streptococcus
pneurnoniae or Staphflococcus aureus (methicillin-sensitive MSSA or resistant
MRSA) and showed significant antibacterial activity against Citrobacter and
Enterobacter.
Cefolesis is well tolerated in clinical studies, being eliminated mainly via
glomerular filtration in humans. | | Originator | Fujisawa (Japan) | | Uses | antibiotic | | Definition | ChEBI: Cefoselis sulfate is an azaheterocycle sulfate salt. It is functionally related to a member of cefoselis. | | Brand name | Wincef |
| | Cefoselis sulfate Preparation Products And Raw materials |
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