ChemicalBook Product Catalog Biochemical Engineering Polypeptide Melanotan 1

Melanotan 1

Melanotan 1 Basic information
Features
Product Name:Melanotan 1
Synonyms:[NLE4,D-PHE]ALPHA-MELANOCYTE STIMULATING HORMONE;(NLE4,D-PHE7)-ALPHA-MSH;[Nle4,D-Phe7]α-MSH;Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2;N-Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2;[Nle4,DPhe7] a-MSH, amide;[Nle4,DPhe7] a-MSH, amide:Melanotan Ⅰ;[Nle4, D-Phe7]-α-MSH, amide
CAS:75921-69-6
MF:C78H111N21O19
MW:1646.85
EINECS:211-519-9
Product Categories:Ion Channel Modulating Peptides;Melanocyte Stimulating Hormones (MSH);ImmunomodulatorsHormones;Obesity Research;Peptides for Cell Biology;Pituitary Hormones;Peptide;Melanocyte Stimulating Hormone (MSH)Peptides and Proteins;α-Melanocyte Stimulating Hormone (α-MSH)Peptides for Cell Biology;Cytokines Growth Factors and Hormones (Obesity);Melanotan II A
Mol File:75921-69-6.mol
Melanotan 1 Structure
Melanotan 1 Chemical Properties
density 1.46±0.1 g/cm3(Predicted)
RTECS OS1830200
storage temp. −20°C
form Solid
pka4.43±0.10(Predicted)
Water Solubility Soluble to 0.60 mg/ml in sterile water
InChIKeyUAHFGYDRQSXQEB-LEBBXHLNSA-N
CAS DataBase Reference75921-69-6(CAS DataBase Reference)
Safety Information
WGK Germany 3
MSDS Information
Melanotan 1 Usage And Synthesis
FeaturesAfamelanotide is a potent, linear synthetic analog of the naturally occurring peptide hormone α-melanocyte-stimulating hormone (α-MSH).Modified to have a stronger binding affinity to melanocortin- 1 receptor (MC1R) and a smaller disassociation constant, afamelanotide has a longer half-life and subsequently exerts longer pharmacologic activity than its parent hormone.
Uses[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice.1It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.
DefinitionChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug.
General Description[Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.
Biochem/physiol Actions[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.
storageStore at -20°C
Melanotan 1 Preparation Products And Raw materials
Melanotan II）,MT-I (a MSH) ALPHA-MSH Melanotan I acetate Melanotan II acetate MELANOTAN II, MT-Ⅱ MelanotanⅠ(α-MSH) Melanotan 1 AC-SYS(NLE)EH(D-PHE)RWGKPVK(BIOTIN)-AMIDE Melanotan,alpha-MSH MELANOTAN II TRIFLUOROACETATE SALT AC-LYS-PRO-VAL-NH2 Melanotan Ⅱ ALPHA-MSH [Nle4, D-Phe7]alfa-MSH, Melanotan I Melanotan Ⅱ Actate,MelanotanⅡAcetate,Melanotan-II(MT-II),Melanotan II acetate salt,Mt-Ii(Melanotan),Melanotan 2,Melanotan Ц,MELANOTAN II Diethylstilbestrol D-Phenylalanine
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