ChemicalBook Product Catalog Chemical Reagents Organic reagents Cyanide / nitrile 3-AMINOPROPIONITRILE FUMARATE

3-AMINOPROPIONITRILE FUMARATE

3-AMINOPROPIONITRILE FUMARATE Basic information
Product Name:3-AMINOPROPIONITRILE FUMARATE
Synonyms:2-Cyanoethylamine hemifumarate;3-Aminopionitrile Fumarate;B-aminopropionitrile monofumarate;di(2-cyanoethylammonium) fumarate;3-AMINOPROPIONITRILE FUMARATE, 99+%;bis(3-aminopropiononitrile) fumarate;3-Aminopropionitrile fumarate, 98+%;3-AMINOPROPIONITRILE FUMARATE (BETA-) 98+%
CAS:2079-89-2
MF:C7H10N2O4
MW:186.17
EINECS:218-208-7
Product Categories:Building Blocks;C1 to C5;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Lysyl oxidase;Enzyme Inhibitors by Enzyme;L to;C1 to C5;Cyanides/Nitriles;Nitrogen Compounds;Inhibitors
Mol File:2079-89-2.mol
3-AMINOPROPIONITRILE FUMARATE Structure
3-AMINOPROPIONITRILE FUMARATE Chemical Properties
Melting point 177 °C (dec.)(lit.)
storage temp. -20°C
form Crystalline Powder
color White
Water Solubility almost transparency
BRN 3573532
CAS DataBase Reference2079-89-2(CAS DataBase Reference)
EPA Substance Registry SystemPropanenitrile, 3-amino-, (2E)-2-butenedioate (2:1) (2079-89-2)
Safety Information
Hazard Codes T
Risk Statements 61
Safety Statements 53-45
WGK Germany 3
RTECS UG0700000
TSCA Yes
HS Code 29269095
ToxicityLDLo orl-rat: 800 mg/kg TJADAB 5,33,72
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
3-AMINOPROPIONITRILE FUMARATE Usage And Synthesis
Chemical PropertiesWHITE CRYSTALLINE POWDER
Uses3-Aminopropionitrile fumarate salt has been used as a lysyl oxidase (LOX) inhibitor:
  • to inhibit collagen cross-linking during microtissue formation and culture
  • in LIM domain only 1 (LMO1)- or vector-expressing BE2C neuroblastoma cell line in transwell migration and invasion assay
  • in lysyl oxidase (LOX) activity assay
  • to study requirement of LOX activity for inducing hypoxia-inducible factor (HIF)2A-dependent stiffness in mouse organoids

DefinitionChEBI: A fumarate salt prepared from beta-aminopropionitrile by reaction of one molecule of fumaric acid for every two molecules of beta-aminopropionitrile.
Biochem/physiol Actions3-Aminopropionitrile (β-Aminopropionitrile (BAPN)) functions as an irreversible inhibitor of lysyl oxidase (LOX), an enzyme involved in collagen cross-linking.
Safety ProfileModerately toxic by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO, and CN-. See also NITRILES.
3-AMINOPROPIONITRILE FUMARATE Preparation Products And Raw materials
3,3'-IMINODIPROPIONITRILE Amino resin 3-Aminopropanol 3-Aminopropionitrile 3-AMINOPROPIONITRILE FUMARATE Fumaric acid Propionitrile
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