ChemicalBook Product Catalog Chemical Reagents Organic reagents Imide N-Hydroxyethylphthalimide

N-Hydroxyethylphthalimide

N-Hydroxyethylphthalimide Basic information
Product Name:N-Hydroxyethylphthalimide
Synonyms:AKOS BBS-00004429;2-PHTHALIMIDOETHANOL;2-(2-hydroxyethyl)-1h-isoindole-1,3(2h)-dione;N-HYDROXYETHYLPHTHALIMIDE;N-(BETA-HYDROXYETHYL)PHTHALIMIDE;TIMTEC-BB SBB003638;1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)-;2-(2-hydroxyethyl)-1h-isoindole-3(2h)-dione
CAS:3891-07-4
MF:C10H9NO3
MW:191.18
EINECS:223-434-4
Product Categories:Building Blocks;Carbonyl Compounds;Chemical Synthesis;Cyclic Imides;Organic Building Blocks;N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Phthalimides;bc0001
Mol File:3891-07-4.mol
N-Hydroxyethylphthalimide Structure
N-Hydroxyethylphthalimide Chemical Properties
Melting point 126-128 °C(lit.)
Boiling point 326.92°C (rough estimate)
density 1.2722 (rough estimate)
refractive index 1.5310 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Crystalline Powder
pka14.40±0.10(Predicted)
color White
BRN 147214
InChIKeyMWFLUYFYHANMCM-UHFFFAOYSA-N
CAS DataBase Reference3891-07-4(CAS DataBase Reference)
NIST Chemistry ReferenceN-2-hydroxyethyl phthalimide(3891-07-4)
EPA Substance Registry System1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)- (3891-07-4)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-26-36/37/39-24/25
WGK Germany 3
TSCA Yes
HS Code 29251900
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
N-Hydroxyethylphthalimide Usage And Synthesis
Chemical Propertieswhite crystalline powder
UsesN-(2-Hydroxyethyl)phthalimide is used as a reagent to synthesize (-)-R-rolipram is a phosphodiesterase 4 inhibitor that is used to treat depression. N-(2-Hydroxyethyl)phthalimide is also used as a reagent to synthesize FR252921, a compound that acts as an immunosuppressant. Amlodipine Impurity 6
Synthesis Reference(s)Organic Syntheses, Coll. Vol. 4, p. 106, 1963
The Journal of Organic Chemistry, 24, p. 1122, 1959 DOI: 10.1021/jo01090a601
General DescriptionN-(2-Hydroxyethyl)phthalimide is the precursor for chloromethyl ethers used in the synthesis of purine acyclic nucleosides.
N-Hydroxyethylphthalimide Preparation Products And Raw materials
Preparation Products1H-Isoindole-1,3(2H)-dione, 2-(2-fluoroethyl)--->2-[(2-Chlorophenyl)Methylene]-4-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]-3-oxobutanoic Acid Ethyl Ester-->2-[2-(2-METHOXY-PHENOXY)-ETHYL]-ISOINDOLE-1,3-DIONE-->Methanesulfonic acid, trifluoro-, 2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl ester
PHT-LEU-OH 2-Hydroxyethylphthalimide tosylate Bismaleimide 2-PHTHALIMIDOPROPIONIC ACID 1-[(2-Chlorophenyl)-N-(methylimino)methyl]cyclopentanol hydrochloride N-PHTHALOYL-DL-GLUTAMIC ANHYDRIDE PHT-MET-OH PHTHALYL-DL-GLUTAMIC ACID N-PHTHALOYL-DL-HISTIDINE DIETHYL 2-PHTHALIMIDOMALONATE-2-13C 2-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONIC ACID METHYL ESTER HydroxyethylPhthalimide727384 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)-3-PHENYLPROPANOIC ACID (S)-AMlodipine-d4 AMlodipine IMpurity F Maleate Amlodipine Impurity 48 d-Amlodipine Dimethyl 4-(2-Chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
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