(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Basic information

Product Name:	(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate
Synonyms:	PyAOP (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1- pyrrolidinylphosphoniuM hexafluorophosphate;(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinyl-phosphorus hexafluorophosphate;tris(pyrrolidin-1-yl)({3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy})phosphanium;(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate 96%;((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphat;7-Azabenzotriazol-1-yloxy)tripyrrolidino-phosphonium hexafluorophosphate≥ 99% (HPLC);PyAOP Novabiochem;(7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluorophosphate
CAS:	156311-83-0
MF:	C17H27F6N7OP2
MW:	521.39
EINECS:	627-192-4
Product Categories:	Coupling Reagent
Mol File:	156311-83-0.mol

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Chemical Properties

Melting point	163-168 °C(lit.)
RTECS	TH3890000
storage temp.	-20°C
solubility	Soluble in water or 1% acetic acid
form	Powder or Crystalline Powder
color	White to off-white
Water Solubility	Soluble in water.
InChIKey	CBZAHNDHLWAZQC-UHFFFAOYSA-N
CAS DataBase Reference	156311-83-0(CAS DataBase Reference)
EPA Substance Registry System	Phosphorus(1+), [3-(hydroxy-.kappa.O)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1) (156311-83-0)

Safety Information

MSDS Information

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Usage And Synthesis

Chemical Properties	(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate is white to off-white crystalline powder
Uses	PyAOP is a phosphonium salt used as a coupling reagent in solid-phase peptide synthesis, without undergoing side reactions with the amino terminus. PyAOP is a derivative of HOAt (H805070).
Uses	(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate is used as a coupling reagent in solid phase peptide synthesis. It is preferred over HATU, because it does not side react at the N-terminus of the peptide. Compared to the HOBt derivates, PyAOP (and HOAt in general) are more reactive due to the additional nitrogen.

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Preparation Products And Raw materials

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