ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound 3-(2-CHLORO-PHENYL)-PYRROLIDINE

3-(2-CHLORO-PHENYL)-PYRROLIDINE

3-(2-CHLORO-PHENYL)-PYRROLIDINE Basic information
Product Name:3-(2-CHLORO-PHENYL)-PYRROLIDINE
Synonyms:2-(3-CHLOROPHENYL)PYRROLIDINE;AKOS BB-8867;CHEMBRDG-BB 4006410;Pyrrolidine, 2-(3-chlorophenyl)-;(+/-)-2-(3-chlorophenyl)-pyrrolidine
CAS:298690-74-1
MF:C10H12ClN
MW:181.66
EINECS:
Product Categories:
Mol File:298690-74-1.mol
3-(2-CHLORO-PHENYL)-PYRROLIDINE Structure
3-(2-CHLORO-PHENYL)-PYRROLIDINE Chemical Properties
Boiling point 138-141 °C(Press: 16 Torr)
density 1.129±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka9.58±0.10(Predicted)
CAS DataBase Reference298690-74-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
HS Code 2933998090
MSDS Information
3-(2-CHLORO-PHENYL)-PYRROLIDINE Usage And Synthesis
UsesUsed as an intermediate for organic synthesis.
Application(+/-)-2-(3-chlorophenyl)-pyrrolidine has a wide application in synthesis of pharma intermediates，It is also used as an antioxidant.
SynthesisTo a solution of substituted benzoic acid inabsolute ethyl alcohol was slowly added thionyl chloride. The mixture was heated to reflux for 2h, and then cooledto room temperature. The solvent was removed and the solid residuewas dissolved in ethyl acetate, and washed withsaturated NaHCO3 solution. After a series of reactions, 3-(2-chloro-phenyl)-pyrrolidine can be obtained.
3-(2-CHLORO-PHENYL)-PYRROLIDINE Preparation Products And Raw materials
Raw materials3-Chlorobenzoic acid
2-(3,4-DICHLOROPHENYL)PYRROLIDINE METHYL 3-(3-CHLOROPHENYL)-5-(4-CHLOROPHENYL)-4,6-DIOXO-1-PHENYLOCTAHYDROPYRROLO[3,4-C]PYRROLE-1-CARBOXYLATE 2-(3-chloro-4-methoxyphenyl)pyrrolidine (R)-2-(3-CHLOROPHENYL)PYRROLIDINE 2-(2,3-dichlorophenyl)pyrrolidine 3-(2-CHLORO-PHENYL)-PYRROLIDINE 2-(5-CHLORO-2-METHOXYPHENYL)PYRROLIDINE (S)-2-(2,3-DICHLOROPHENYL)PYRROLIDINE METHYL 4-BENZYL-6-(3-CHLORO-4-METHOXYPHENYL)-1,3-DIOXOHEXAHYDRO-1H-FURO[3,4-C]PYRROLE-4-CARBOXYLATE METHYL (3S)-2-(3,4-DICHLOROPHENYL)-3-PYRROLIDINECARBOXYLATE HYDROCHLORIDE 2-(2,5-dichlorophenyl)pyrrolidine (R)-2-(5-CHLORO-2-METHOXYPHENYL)PYRROLIDINE (S)-2-(3-CHLOROPHENYL)PYRROLIDINE (R)-2-(3,4-DICHLOROPHENYL)PYRROLIDINE (R)-2-(2,3-DICHLOROPHENYL)PYRROLIDINE METHYL 1,5-DIBENZYL-3-(3-CHLOROPHENYL)-4,6-DIOXOOCTAHYDROPYRROLO[3,4-C]PYRROLE-1-CARBOXYLATE 2-(3-chloro-4-fluorophenyl)pyrrolidine (S)-2-(5-CHLORO-2-METHOXYPHENYL)PYRROLIDINE
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