ChemicalBook Product Catalog Pharmaceutical intermediates Bulk Drug Intermediates 7-Fluoroindole

7-Fluoroindole

7-Fluoroindole Basic information
Product Name:7-Fluoroindole
Synonyms:BUTTPARK 24\07-35;7-FLUOROINDOLE;7-FLUORO-1H-INDOLE;1H-Indole, 7-fluoro-;7-ETHOXYINDOLE;7-Fluoroindoline-2-one;7-Fluoroindole,97%;6-(2-(diMethylaMino)vinyl)-5-nitropyriMidine-2,4(1H,3H)-dione
CAS:387-44-0
MF:C8H6FN
MW:135.14
EINECS:640-248-2
Product Categories:Building Blocks;C7 to C10;C7 to C9;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Heterocycles;Indoles;Simple Indoles;Fluorinated heterocyclic series;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;New Products for Chemical Synthesis;Other Fluorinated Heterocycles;Fluorine series;Indoles and derivatives;Indole
Mol File:387-44-0.mol
7-Fluoroindole Structure
7-Fluoroindole Chemical Properties
Melting point 61 °C
Boiling point 258.0±13.0 °C(Predicted)
density 1.273±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in methanol. (almost transparency)
pka15.55±0.30(Predicted)
form powder to crystal
color White to Light yellow to Light orange
BRN 114740
InChIKeyXONKJZDHGCMRRF-UHFFFAOYSA-N
CAS DataBase Reference387-44-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-41-37/38-22
Safety Statements 26-36-39
WGK Germany 3
Hazard Note Irritant
HS Code 29339900
MSDS Information
ProviderLanguage
ALFA English
7-Fluoroindole Usage And Synthesis
Chemical PropertiesBrown solid
Uses7-Fluoroindole is a reagent used in chemical synthesis. It has been used to synthesize antiviral compounds against Pseudomonas aeruginosa and Staphylococcus aureus along with creation of immunomodulators. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
Antimicrobial activity7-fluoroindole (7FI) was identified as a compound that inhibits biofilm formation and blood hemolysis without inhibiting the growth of planktonic P. aeruginosa cells. Moreover, 7FI markedly reduced the production of quorum-sensing (QS)-regulated virulence factors 2-heptyl-3-hydroxy-4(1H)-quinolone, pyocyanin, rhamnolipid, two siderophores, pyoverdine and pyochelin. 7FI clearly suppressed swarming motility, protease activity and the production of a polymeric matrix in P. aeruginosa. However, unlike natural indole compounds, synthetic 7FI did not increase antibiotic resistance. Therefore, 7FI is a potential candidate for use in an antivirulence approach against persistent P. aeruginosa infection.
7-Fluoroindole Preparation Products And Raw materials
Raw materialsTetrahydrofuran-->Vinylmagnesium bromide-->1-Fluoro-2-nitrobenzene
Preparation Products7-FLUOROINDOLINE
Ethyl-4-Fluoroindole-2-Carboxylate N,N-DIETHYL-4,5,6,7-TETRAFLUORO-3-INDOLEACETAMIDE 4,5,6,7-TETRAFLUORO-N-(2-METHOXYETHYL)-3-INDOLEACETAMIDE 4,5,6,7-TETRAFLUOROINDOLE-3-CARBOXALDEHYDE Flucindole FMOC-L-TRP(4,5,6,7-TETRAFLUORO) 8-FLUORO-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE 4,7-DIFLUOROINDOLE 4,5,6,7-TETRAFLUORO-N-(2-MORPHOLINOETHYL)-3-INDOLEACETAMIDE 7-Fluoroindole 5,7-Difluoroindole 4,5,6,7-TETRAFLUORO-3-INDOLEACETONITRILE 2-(5-BROMO-7-FLUORO-2-METHYL-1H-INDOL-3-YL)ETHYLAMINE OXALATE 2-(7-FLUORO-2-METHYL-1H-INDOL-3-YL)-ETHYLAMINE (4,5,6,7-TETRAFLUORO-1H-INDOL-3-YL)ACETIC ACID 2-(5,7-DIFLUORO-2-METHYL-1H-INDOL-3-YL)-ETHYLAMINE Lurosetron 5,7-Difluoroindole-2-carboxylic acid
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