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| | AC-YVAD-CHO Basic information |
| Product Name: | AC-YVAD-CHO | | Synonyms: | N-ACETYL-L-TYROSYL-L-VALYL-N-[(1S)-2-CARBOXYL-1-FORMYLETHYL]-L-ALANINAMIDE;N-ACETYL-TYR-VAL-ALA-ASP-CHO (ALDEHYDE);N-ACETYL-TYR-VAL-ALA-GLU-AL;N-AC-TYR-VAL-ALA-ASP-CHO;N-ACETYL-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-TYR-VAL-ALA-ASP-CHO (ALDEHYDE);TYR-VAL-ALA-ASP-CHO;YVAD-CHO;ICE INHIBITOR | | CAS: | 143313-51-3 | | MF: | C23H32N4O8 | | MW: | 492.52 | | EINECS: | | | Product Categories: | Caspases/Apoptosis;peptide;Pepetides;peptides | | Mol File: | 143313-51-3.mol |  |
| | AC-YVAD-CHO Chemical Properties |
| Boiling point | 937.7±65.0 °C(Predicted) | | density | 1.276±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMF:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);10.15(Max Conc. mM) | | form | Powder | | pka | 4.20±0.10(Predicted) | | Sensitive | Moisture Sensitive |
| | AC-YVAD-CHO Usage And Synthesis |
| Description | Ac-YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE; Ki = 0.76 nM) and an acetylated form of the caspase-1 inhibitor YVAD-CHO . It is selective for caspase-1 over caspase-4, -5, -8, -9, and -10 (Kis = 163-970 nM), as well as over caspase-2, -3, -6, and -7 (Kis = >10,000 nM for all). It inhibits activation of caspase-1 and IL-1β in a cell-free assay using LPS-treated THP-1 cell homogenates when used at a concentration of 5 μM. Ac-YVAD-CHO (12.5 μmol/kg) reduces pancreatic levels of IL-18 and serum levels of IL-1β, as well as reduces pyroptosis of pancreatic cells, in a mouse model of cerulein-induced acute pancreatitis but does not decrease pancreatic expression of NOD-like receptor protein 3 (NLRP3). It increases susceptibility to lethal E. coli infection but prevents LPS-induced death in C3H/HeN mice when administered at doses of 5 and 10 mg/kg, respectively. | | Uses | A potent, specific, and reversible inhibitor of caspases-1, -4 and -5 |
| | AC-YVAD-CHO Preparation Products And Raw materials |
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