N-Fluorobenzenesulfonimide

N-Fluorobenzenesulfonimide Basic information

Product Name:	N-Fluorobenzenesulfonimide
Synonyms:	NFSI;N-FLUOROBENZENESULFONAMIDE;N-FLUOROBENZENESULFONIMIDE;N-FLUOROBENZENESULPHONIMIDE;N-FLUOROBIS(PHENYLSULFONYL)AMINE;N-FLUORODIBENZENESULFONAMIDE;N-Fluorobenzenesulfonimide(NFSI);N-FluorobenzenesulfonMide (NFA)
CAS:	133745-75-2
MF:	C12H10FNO4S2
MW:	315.34
EINECS:	000-000-0
Product Categories:	kl;Synthetic Organic Chemistry;Electrophilic Fluorinating Reagents;Fluorinating Reagents;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;alkyl Fluorine;Fluorination;Halogenation
Mol File:	133745-75-2.mol

N-Fluorobenzenesulfonimide Chemical Properties

Melting point	114-116 °C
Boiling point	471.4±28.0 °C(Predicted)
density	1.4466 (estimate)
Fp	110℃
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Very soluble in acetonitrile, dichloromethane or THF and less soluble in toluene.
pka	-32.45±0.70(Predicted)
form	solid
color	white
BRN	5348902
InChIKey	RLKHFSNWQCZBDC-UHFFFAOYSA-N
CAS DataBase Reference	133745-75-2(CAS DataBase Reference)

Safety Information

MSDS Information

N-Fluorobenzenesulfonimide Usage And Synthesis

Chemical Properties	Off-white to light brown crystalline powder
Uses	Versatile fluorinating reagent used in the fluorination of aryls, enolates, carbanions, organolithiums, etc.
Uses	N-Fluorobenzenesulfonimide fluorinates aromatics, enolates, azaenolates and carbanions in high yield. It is used for diastereoselective fluorination of Li enolates of chiral carboximides, for directed fluorination of ortho-lithiated aromatics and for a review of electrophilic N-F fluorinating agents. Asymmteric fluorinations is effected in the presence of a Pd-BINAP catalyst system at room temperature in an ionic liquid. It is a reagent employed in a palladium-catalyzed enantioselective fluorination of t-butoxycarbonyl lactones and lactams. It is also used in the electrophilic difluorination of dihalopyridines with butyl lithium and in the direct conversion of alcohols to dibenzenesulfonamides with triphenylphosphine.
Application	N-Fluorobenzenesulfonimide is a mild electrophilic fluorinating reagent, that can also be used as a strong oxidant for the promotion of reductive elimination from transition metals.
General Description	N-Fluorobenzenesulfonimide (NFSi) is a commonly used electrophilic fluorinating agent in organic synthesis to introduce fluorine into neutral organic molecules. It is also used to fluorinate nucleophilic substrates such as reactive organometallic species and malonate anions. NFSi can be synthesized by the reaction of benzenesulfonimide with fluorine.

N-Fluorobenzenesulfonimide Preparation Products And Raw materials

Preparation Products

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