4-Chlorobenzhydrylchloride

4-Chlorobenzhydrylchloride Basic information

Product Name:	4-Chlorobenzhydrylchloride
Synonyms:	P-CHLOROBENZHYDRYL CHLORIDE;1-chloro-4-(chlorophenylmethyl)-benzen;Benzene,1-chloro-4-(chlorophenylmethyl)-;Benzene,1-chloro-4-(chlorophenylmethyl)-4-Chlorobenzhydrylchloride;Chloro[4-chlorophenyl]phenylmethone;Methane, chloro(p-chlorophenyl)phenyl-;4-CHLOROBENZHYDRYL CHLORIDE;4-CHLORO DIPHENYL METHANE CHLORIDE
CAS:	134-83-8
MF:	C13H10Cl2
MW:	237.12
EINECS:	205-158-6
Product Categories:
Mol File:	134-83-8.mol

4-Chlorobenzhydrylchloride Chemical Properties

Boiling point	159-160 °C2 mm Hg(lit.)
density	1.239 g/mL at 25 °C(lit.)
refractive index	n20/D 1.603(lit.)
Fp	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
form	clear liquid
color	Colorless to Light yellow to Light orange
Water Solubility	IMMISCIBLE
Sensitive	Moisture Sensitive
BRN	2050236
CAS DataBase Reference	134-83-8(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1-chloro-4-(chlorophenylmethyl)-(134-83-8)
EPA Substance Registry System	Benzene, 1-chloro-4-(chlorophenylmethyl)- (134-83-8)

Safety Information

Hazard Codes	C
Risk Statements	34-36/37-36
Safety Statements	26-27-36/37/39-45
RIDADR	UN 3265 8/PG 2
WGK Germany	3
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29036990

MSDS Information

Provider	Language
Chloro(4-chlorophenyl)phenylmethane	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Chlorobenzhydrylchloride Usage And Synthesis

Chemical Properties	clear light yellow liquid
Uses	1-Chloro-4-(chlorophenylmethyl)benzene is used in the synthesis of novel benzhydrylpiperazine derivatives as cytotoxic compounds in the treatment of various cancers.
Preparation	Preparation of 4-Chlorobenzhydryl Chloride (4-CBC): The 4-chlorobenzhydrol (4-CB) in 15 mL of toluene, obtained from the previous step, was mixed with 10 mL of conc. HCl at 60oC maintained at the same temperature for 2.5 h. The reaction mixture was cooled to 20oC to separate into organic and aqueous layers. The toluene layer was washed with 10 % aq. sodium carbonate to pH 7, dried over anhydrous sodium sulphate and taken to next step without isolation.

4-Chlorobenzhydrylchloride Preparation Products And Raw materials

Raw materials	Ethyl acetate-->Thionyl chloride-->PETROLEUM ETHER-->Toluene-->Magnesium sulfate-->4-Chlorobenzhydrol
Preparation Products	1-(4-Chlorobenzhydryl)piperazine-->4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE

3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide 1,1'-(chloromethylene)bis[4-chlorobenzene] 1,1-BIS(4-CHLOROPHENYL)-1,2,2,2-TETRACHLOROETHANE Diphenylmethane 3,4'-DIAMINODIPHENYLMETHANE 4-Chlorobenzhydrylchloride AKOS 94028 dichloro[(dichlorophenyl)methyl]methylbenzene Chlorophenyl Difluorochloromethane Benzene 4,4'-(ALPHA,4-DICHLOROBENZYLIDENE)BIS[2,2'-(PHENYLIMINO)DIETHANOL] 4,4'-Methylenedianiline 1-[CHLORO(4-CHLOROPHENYL)METHYL]-2,3,4,5,6-PENTAMETHYLBENZENE Triphenylmethyl Chloride Chlorofluoromethane Chlorodiphenylmethane Chloromethane

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