3-（trifluoromethyl) Cinnamaldehyde

3-（trifluoromethyl) Cinnamaldehyde Basic information

Product Name:	3-（trifluoromethyl) Cinnamaldehyde
Synonyms:	3-（trifluoromethyl) Cinnamaldehyde;(2E)-3-[3-(Trifluoromethyl)phenyl]prop-2-enal;(E)-3-(3-(TrifluoroMethyl)phenyl)acrylaldehyde;2-Propenal,3-[3-(trifluoroMethyl)phenyl]-, (2E)-;:3-(TrifluoroMethyl)cinnaMaldehyde CAS:262268-58-6;Cinacalcet Impurity 55;3-（trifluoromethyl) Cinnamaldehyde USP/EP/BP;(E)-3-(3-(Trifluoromethyl)phenyl)acrylaldehyde,trans-m-trifluoromethylcinnamaldehyde,m-trifluoromethylcinnamaldehyde
CAS:	262268-58-6
MF:	C10H7F3O
MW:	200.16
EINECS:	1312995-182-4
Product Categories:	Aromatic Cinnamic Acids, Esters and Derivatives
Mol File:	262268-58-6.mol

3-（trifluoromethyl) Cinnamaldehyde Chemical Properties

Boiling point	257℃
density	1.241
Fp	107℃
storage temp.	Amber Vial, Refrigerator, Under inert atmosphere
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly)
form	Off-White to Pale Yellow Semi-Solid
Stability:	Air Sensitive, Light Sensitive

Safety Information

MSDS Information

3-（trifluoromethyl) Cinnamaldehyde Usage And Synthesis

Uses	(E)-3-(3-(Trifluoromethyl)phenyl)acrylaldehyde is an intermediate used in the synthesis of (E)-2,3,-Dehydro-cinacalcet, which is an impurity of Cinacalcet Hydrochloride (C441800). Cinacalcet is used in clinical trial in secondary hyperparathyroidism.

3-（trifluoromethyl) Cinnamaldehyde Preparation Products And Raw materials

Raw materials	3-(Trifluoromethyl)cinnamic acid-->3-(3-Trifluoromethyl-phenyl)-prop-2-en-1-ol-->(FORMYLMETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE-->3-Iodobenzotrifluoride-->3-(Trifluoromethyl)benzaldehyde-->Acrolein diethyl acetal-->Acetaldehyde-->3-Bromobenzotrifluoride-->(FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE
Preparation Products	3-(3'-TRIFLUOROMETHYL PHENYL) PROPANOL-->3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER-->3-(3-Trifluoromethylphenyl)propionic acid

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