|
| | HEXAHYDROCURCUMIN Basic information |
| Product Name: | HEXAHYDROCURCUMIN | | Synonyms: | HEXAHYDROCURCUMIN;5-Hydroxy-1-(4-hydroxy-3-Methoxycyclohexyl)-7-(4-hydroxy-3-Methoxyphenyl)heptan-3-one;(RS)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone;1,7-Bis(3-methoxy-4-hydroxyphenyl)-5-hydroxy-3-heptanone;1,7-Bis(4-hydroxy-3-methoxyphenyl)-5-hydroxyheptan-3-one;5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone;Hexahydrocurcumin, BR;3-Heptanone, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)- | | CAS: | 36062-05-2 | | MF: | C21H26O6 | | MW: | 374.43 | | EINECS: | | | Product Categories: | | | Mol File: | 36062-05-2.mol |  |
| | HEXAHYDROCURCUMIN Chemical Properties |
| Melting point | 80-82℃ | | Boiling point | 622.6±55.0 °C(Predicted) | | density | 1.226 | | Fp | 218℃ | | storage temp. | 2-8°C | | solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly), DCM, DMSO | | pka | 10.02±0.20(Predicted) | | form | neat | | color | Pale Yellow | | BRN | 2486876 |
| | HEXAHYDROCURCUMIN Usage And Synthesis |
| Description | Hexahydrocurcumin is a natural product and glucuronide metabolite of curcumin that has anti-inflammatory, antioxidant, and anticancer properties. It reduces prostaglandin E2 (PGE2) production stimulated by phorbol 12-myristate 13-acetate (PMA; ) by 37% in human colonic epithelial cells when used at a concentration of 20 μM. Hexahydrocurcumin (3.125-25 μM) inhibits overproduction of nitric oxide induced by LPS in RAW 264.7 macrophage cells in a concentration-dependent manner. It does not affect LPS-induced cytokine release but inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation when used at a concentration of 50 μM. Hexahydrocurcumin prevents the formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer and potentiates the effect of 5-fluorouracil . | | Uses | Hexahydrocurcumin is an intermediate in the synthesis of Gingerenone A (G387500) which is an antifungal and antiparasitic diarylheptenone that is isolated from Zingiber officinale (more commonly known as ginger), a medicinal plant that is used to treat inflammation and musculoskeletal disorders. | | Definition | ChEBI: Hexahydrocurcumin is a diarylheptanoid. | | target | PGE | NOS | COX |
| | HEXAHYDROCURCUMIN Preparation Products And Raw materials |
|
