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L-Tyrosine Ethyl Ester Hydrochloride

L-Tyrosine Ethyl Ester Hydrochloride Basic information
Product Name:L-Tyrosine Ethyl Ester Hydrochloride
Synonyms:(S)-2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID ETHYL ESTER HCL;TEE;ethylester,hydrochloride,l-tyrosin;tyrosineethylesterhydrochloride;TYROSINE-OET HCL;Tyr-Oet Hcl;L-TYROSINE ETHYL ESTER MONOHYDROCHLORIDE;L-TYROSINE ETHYL ESTER HYDROCHLORIDE SALT
CAS:4089-07-0
MF:C11H16ClNO3
MW:245.7
EINECS:223-820-2
Product Categories:Amino Acids;I - ZPeptide Synthesis;Tyrosine [Tyr, Y];Amino Acids and Derivatives;Amino Acid Derivatives;Modified Amino Acids;Amino Acids;Amino Acid Ethyl Esters;Amino Acids (C-Protected);Biochemistry;Amino hydrochloride;Peptide Synthesis;Tyrosine
Mol File:4089-07-0.mol
L-Tyrosine Ethyl Ester Hydrochloride Structure
L-Tyrosine Ethyl Ester Hydrochloride Chemical Properties
Melting point 166-170 °C
alpha [α]D20 +26～+30° (c=5, C2H5OH)
refractive index -6.5 ° (C=2, H2O)
storage temp. Sealed in dry,Room Temperature
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form powder to crystal
color White to Almost white
Water Solubility Soluble in water (3.685e+005 mg/L @ 25°C (est.)).
BRN 4725904
InChIKeyBQULAXAVRFIAHN-PPHPATTJSA-N
LogP1.060 (est)
CAS DataBase Reference4089-07-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-37/39-26
WGK Germany 2
RTECS YP2580000
HS Code 29225090
MSDS Information
ProviderLanguage
Ethyl L-tyrosinate hydrochloride English
SigmaAldrich English
ACROS English
ALFA English
L-Tyrosine Ethyl Ester Hydrochloride Usage And Synthesis
Chemical PropertiesWhite to off-white microcrystalline powder
UsesL-Tyrosine Ethyl Ester Hydrochloride is used as a medical and organic intermediate and as an important amino protective agent. It is also used to introduce t-Boc protect gene.
ApplicationPapain is also used for synthesizing poly(L-tyrosine) and poly(L-glutamic acid) using L-tyrosine ethyl ester hydrochloride and L-glutamic acid diethyl ester hydrochloride as the substrates, respectively. The protease-catalyzed copolymerization of amino acids is first achieved by papain using L-glutamic acid ester and various amino acid esters as substrates.
A mixture of L-tyrosine ethyl ester hydrochloride, the appropriate acid anhydri-des, triethylamine and dry tetrahydrofuran, was warmed for an hour in an atmosphere of nitrogen. After removing the amine salt, Ic and Id became crystalline on standing overnight in the cold.
Preparationsynthesis of L-Tyrosine Ethyl Ester Hydrochloride: Esterification of 25 g. ol L-tyrosine (0.014 mole) with ethanolic hydrogen chloride gave 24.1 g. of L-tyrosine ethyl ester hydrochloride (80%). Liberation of the ester by slurrying the hydrochloride in chloroform rollowed by the addition of chloroform saturated with ammonia, removal of the ammonium chloride by filtration and evaporation of the chloroform gave 19.4 g. of L-tyrosine ethyl ester (67%), m.p. 106-108 ° .
L-Tyrosine Ethyl Ester Hydrochloride Preparation Products And Raw materials
Raw materialsHydrochloric acid
Preparation ProductsN-Glycyl-L-tyrosine-->Ethyl L-tyrosinate-->L-TYROSINOL
Ethyl L-tyrosinate L-Tyrosine H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH TYROSINASE Ethanol Boc-D-Tyr-OH Topotecan hydrochloride Ethyl formate Tris(trimethylsilyl)phosphate L-Tyrosine Ethyl Ester Hydrochloride Ethylparaben Glycine ethyl ester hydrochloride ISOXADIFEN-ETHYL L-Tyrosine hydrochloride Ethyl acetate Methyl L-tyrosinate hydrochloride Ethyl acrylate Ethyl cyanoacetate
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