(9S)-9-Amino-9-deoxoerythromycin

(9S)-9-Amino-9-deoxoerythromycin Basic information

Product Name:	(9S)-9-Amino-9-deoxoerythromycin
Synonyms:	(9S)-9-Amino-9-deoxoerythromycin;(9S)-9-amino-9-deoxyerythromycin;9-Amino-9-deoxo-erythromycin, stereoisomer;9-Epierythromycylamine;Brn 4241492;Epierythromycyl-A-amine;Erythromycin, 9-amino-9-deoxo-, (9S)- (9ci);Erythromycin, 9-amino-9-deoxo-, stereoisomer
CAS:	26116-56-3
MF:	C37H70N2O12
MW:	734.96
EINECS:	406-790-7
Product Categories:	Intermediates & Fine Chemicals;Metabolites & Impurities;Various Metabolites and Impurities;Pharmaceuticals
Mol File:	26116-56-3.mol

(9S)-9-Amino-9-deoxoerythromycin Chemical Properties

Melting point	123-127°C
Boiling point	810.3±65.0 °C(Predicted)
density	1.19±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMF: 15 mg/ml; DMSO: 15 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
form	A solid
pka	13.41±0.70(Predicted)

Safety Information

Hazard Codes	Xi,N
Risk Statements	41-50/53
Safety Statements	26-39-60-61
Toxicity	mouse,LD50,intraperitoneal,120mg/kg (120mg/kg),European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 13, Pg. 83, 1978.

MSDS Information

(9S)-9-Amino-9-deoxoerythromycin Usage And Synthesis

Chemical Properties	(9S)-9-Amino-9-deoxoerythromycin is White Solid
Uses	(9S)-9-Amino-9-deoxoerythromycin is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. (9S)-9-Amino-9-deoxoerythromycin is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine.
Uses	Erythromycylamine is a semi-synthetic analogue of erythromycin prepared by reduction of erythromycin oxime. Erythromycylamine is a potent antibiotic, however the introduction of the amino- moiety increases the compound’s polarity and is disadvantageous for in vivo use. This limitation was overcome by the synthesis of dirithromycin, a Schiff base pro-drug that dissociates in vivo to erythromycylamine.
Uses	(9S)-9-Amino-9-deoxoerythromycin is a metabolite of Dirithromycin; an antibiotic
Definition	ChEBI: A macrolide antibiotic that is erythromycin A in which the ketone group has been converted to the corresponding imine and then reduced to give the corresponding amino compound (the 9S diastereoisomer).

(9S)-9-Amino-9-deoxoerythromycin Preparation Products And Raw materials

Login