ChemicalBook Product Catalog Chemical Reagents Organic reagents aliphatic ketones 1,1,1-Trifluoroacetone

1,1,1-Trifluoroacetone

1,1,1-Trifluoroacetone Basic information
Product Name:1,1,1-Trifluoroacetone
Synonyms:TRIFLUOROACETONE;1,1,1-trifluoro-2-propanon;3,3,3-Trifluoroacetone;CH3COCF3;Methyl trifluoromethyl ketone;Trifluoromethyl methyl ketone;1,1,1-TRIFLUOROACETONE;1,1,1-TRIFLUORO-2-PROPANONE
CAS:421-50-1
MF:C3H3F3O
MW:112.05
EINECS:207-005-9
Product Categories:C3 to C6;Carbonyl Compounds;Ketones
Mol File:421-50-1.mol
1,1,1-Trifluoroacetone Structure
1,1,1-Trifluoroacetone Chemical Properties
Melting point -78 °C
Boiling point 22 °C(lit.)
density 1.252 g/mL at 25 °C(lit.)
vapor pressure 13.62 psi ( 20 °C)
refractive index n20/D 1.3(lit.)
Fp −23 °F
storage temp. 2-8°C
solubility Chloroform, Methanol
form Liquid
color Clear colorless
Water Solubility Miscible
Sensitive Lachrymatory
BRN 1748614
Stability:Volatile
InChIKeyFHUDAMLDXFJHJE-UHFFFAOYSA-N
CAS DataBase Reference421-50-1(CAS DataBase Reference)
NIST Chemistry Reference2-Propanone, 1,1,1-trifluoro-(421-50-1)
EPA Substance Registry System2-Propanone, 1,1,1-trifluoro- (421-50-1)
Safety Information
Hazard Codes F+,Xi,F
Risk Statements 12-36/37/38
Safety Statements 16-26-29-33-36-7/9-9-37/39-39
RIDADR UN 1993 3/PG 1
WGK Germany 3
F 19
Hazard Note Flammable/Lachrymatory
TSCA T
HazardClass 3
PackingGroup I
HS Code 29147090
MSDS Information
ProviderLanguage
1,1,1-Trifluoro-2-propanone English
SigmaAldrich English
ACROS English
ALFA English
1,1,1-Trifluoroacetone Usage And Synthesis
Chemical Properties1,1,1-Trifluoroacetone is CLEAR COLOURLESS LIQUID
Uses1,1,1-Trifluoroacetone is used as intermediate of bioactive substance and antihypertensive drug, and as effective synthetic building block and trifluoromethyl reaction reagent.
Uses1,1,1-Trifluoroacetone is a general chemical reagent used in the synthesis of glucokinase-glucokinase regulatory protein) GK-GKRP disruptors which may act as potential targets for type II diabetics. Reactant for enantioselective cycloadditions.
UsesUsed in a synthesis of 2-trifluoromethyl-7-azaindoles starting with 2,6-dihalopyridines. The derived chiral imine was used to prepare enantiopure α-trifluoromethyl alanines and diamines via a Strecker reaction followed by either nitrile hydrolysis or reduction.
1,1,1-Trifluoroacetone Preparation Products And Raw materials
Preparation ProductsHEXAFLUOROACETYLACETONE-->3-Thiophenecarboxylic acid, 2-amino-4-(trifluoromethyl)-, ethyl ester-->4-Amino-2-(trifluoromethyl)quinoline-->trifluoromethylglyoxal-bis(guanylhydrazone)-->2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBALDEHYDE-->2-METHYL-4-TRIFLUOROMETHYL-NICOTINIC ACID-->Butanoic acid, 4,4,4-trifluoro-2,3-dihydroxy-3-methyl--->2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBOXYLIC ACID-->Ethyl 3-hydroxy-3-methyl-4,4,4-trifluorobutyrate-->2-Butenoic acid, 4,4,4-trifluoro-3-methyl-, methyl ester-->1,1,1-trifluoro-4-morpholin-4-yl-3-(morpholin-4-ylmethyl)butane-2,2-di ol-->1,1,1,5,5,6,6,6-OCTAFLUORO-2,4-HEXANEDIONE
1,1,3-Trichloroacetone METHYL TRIFLUOROPYRUVATE Acetylacetone 4'-METHOXY-2,2,2-TRIFLUOROACETOPHENONE Thenoyltrifluoroacetone Citric acid monohydrate 3-BROMO-1,1,1-TRIFLUOROACETONE,1-BROMO-3,3,3-TRIFLUOROACETONE 97%,1-BROMO-3,3,3-TRIFLUOROACETONE,3-Bromo-1,1,1-trifluoroacetone, min. 97% Phenylacetone 1,1,1-Trifluoroacetone Triacetonamine Trifluoroacetic acid Calcium pyruvate Pyruvic acid 4,4,4-Trifluoro-1-phenyl-1,3-butanedione ACETYL TRIFLUOROACETONE Ethyl trifluoropyruvate Propiophenone ZIRCONIUM TRIFLUOROACETYLACETONATE
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