ChemicalBook Product Catalog Biochemical Engineering ANTI-CYTOCHROME C

ANTI-CYTOCHROME C

ANTI-CYTOCHROME C Basic information
Product Name:ANTI-CYTOCHROME C
Synonyms:ANTI-APAF-2 (AB-1), RABBIT;ANTI-APAF-2 (AB-1) SHEEP PAB;ANTI-APAF-2 (AB-2), MAMMALIAN;ANTI-HUMAN CYTOCHROME C;ANTI-HUMAN/MOUSE/RAT CYTOCHROME C;ANTI-CYTOCHROME C(H-104);ANTI-CYTOCHROME C MAB;ANTI-CYTOCHROME C MOUSE MAB
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MW:0
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Mol File:Mol File
ANTI-CYTOCHROME C Structure
ANTI-CYTOCHROME C Chemical Properties
storage temp. -20°C
form buffered aqueous solution
Safety Information
Hazard Codes Xn
Risk Statements 21/22
Safety Statements 36/37
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
ANTI-CYTOCHROME C Usage And Synthesis
UsesAnti-Cytochrome c antibody produced in sheep has been used in:
  • immunocytochemistry
  • immunostaining
  • immunoblotting
  • immunohistochemistry

General DescriptionAnti-Cytochrome c produced in sheep using purified rabbit cytochrome c conjugated to keyhole limpet hemocyanin (KLH).
Biochem/physiol ActionsCytochrome c controls cellular electron transport and energy metabolism. It is involved in the transfer of electrons between complex III and complex IV in the mitochondrial electron transport chain. It is involved in apoptosis and activates the death protease caspase-3 (CCP32). The presence of Bcl-2 on the organelles inhibits the release of cytochrome c from mitochondria during apoptosis. Along with Apaf-1, and procaspase-9, it forms an essential component of vertebrate ”apoptosome”. Activation of caspase-9 and other capsases directs apoptosis. Serum cytochrome c is a sensitive apoptotic marker in vivo, and increased serum cytochrome c level can serve as a negative prognostic marker.
ANTI-CYTOCHROME C Preparation Products And Raw materials
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