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Loperamide

Loperamide Basic information
Product Name:Loperamide
Synonyms:loperamide oxide;R 58425;trans-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutanamide 1-oxide;trans-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide 1-oxide monohydrate;Loperamide EP Impurity F;4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide N-oxide;LoperaMide-d6 N-Oxide;Loperamide impurity-F(EP)
CAS:106900-12-3
MF:C29H33ClN2O3
MW:493.04
EINECS:
Product Categories:Amines;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Metabolites & Impurities;Pharmaceuticals
Mol File:106900-12-3.mol
Loperamide Structure
Loperamide Chemical Properties
solubility Practically insoluble in water, freely soluble in alcohol and in methylene chloride.
form neat
pka12.94±0.20(Predicted)
Stability:Hygroscopic
Safety Information
RIDADR UN 2811 6.1 / PGIII
RTECS TM4960200
HS Code 2933399090
MSDS Information
Loperamide Usage And Synthesis
Chemical PropertiesWhite or almost white powder, slightly hygroscopic.
UsesLoperamide oxide (LOPOX) is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.
UsesLabelled Loperamide oxide (LOPOX). It is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.
DefinitionChEBI: Loperamide oxide is a diarylmethane.
Loperamide Preparation Products And Raw materials
2,2-DIPHENYLPROPYLAMINE HYDROCHLORIDE DESMETHYL LOPERAMIDE TRIETHYLAMINE N-OXIDE 4-(4-CHLOROPHENYL)PIPERIDINE DIPHENAMID 4-(4-Chlorophenyl)piperidin-4-ol fenpipramide Loperamide Alverine Trimethylamine N-oxide dihydrate Trimethylamine N-oxide (R)-1-(4-CHLOROPHENYL)-1-PROPANOL (Diphenyl-3,3 propyl)-1 phenyl-4 piperidine chlorhydrate [French] Loperamide 1-(4-CHLORO-PHENYL)-3-DIMETHYLAMINO-PROPAN-1-OL
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