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N-Desmethyl Imatinib

N-Desmethyl Imatinib Basic information
Product Name:N-Desmethyl Imatinib
Synonyms:CGP-74588;N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide;Norimatinib;STI 509-00;Imatinib impurity 6/Imatinib EP Impurity C/N-Desmethyl Imatinib/N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide;Benzamide,N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-;IMATINIB METABOLITE N-DESMETHYL IMATINIB (N-DESMETHYL IMATINIB);N-{4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4-(piperazin-1-ylmethyl)benzamide
CAS:404844-02-6
MF:C28H29N7O
MW:479.58
EINECS:1592732-453-0
Product Categories:Metabolite Reference Standard;Isotopically Labeled Pharmaceutical Reference Standard;Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals;Tyrosine Kinase Inhibitors;Various Metabolites and Impurities
Mol File:404844-02-6.mol
N-Desmethyl Imatinib Structure
N-Desmethyl Imatinib Chemical Properties
Melting point 99-101°C
density 1.268±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml
form A lyophilized solid
pka13.28±0.70(Predicted)
Safety Information
Safety Statements 24/25
HS Code 29339900
MSDS Information
N-Desmethyl Imatinib Usage And Synthesis
DescriptionN-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC50 = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.
Chemical PropertiesOff-White to Pale-Yellow Solid
Usesaminoglycoside antibiotic similar to gentamycin, toxic to bacterial, yeast, higher plant and mammalian cells and to protozoans and helminthes
Usesanti-epileptic
UsesN-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.
DefinitionChEBI: N-Demethylated piperazine is a member of benzamides.
N-Desmethyl Imatinib Preparation Products And Raw materials
4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide N-DESMETHYL IMATINIB Imatinib Impurity 7 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine Imatinib Meta-methyl-piperazine Impurity IMatinib Para-diaMinoMethylbenzene Guanidine, N-(2-methyl-3-nitrophenyl)- 1,4-Bis-[4-[4-Methyl-3-[[4-(pyridin-3-yl)pyriMidin-2-yl]aMino]phenyl]carbaMoyl]benzylpiperazine Imatinib EP Impurity D 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid iMatinib related substance B N-(3-GUANIDINO-4-METHYLPHENYL)-4-(METHYLPIPERAZINE-1-YL-METHYL)BENZAMIDE Imatinib EP Impurity J Imatinib iMatinib related substance C 3-Acetylpyridine N-Desmethyl Imatinib
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