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| | (+)-MENTHOL Basic information |
| Product Name: | (+)-MENTHOL | | Synonyms: | C00553;(+)-Menthol, (1S,2R,5S)-2-Isopropyl-5-methylcyclohexanol;(1S,3S,4R)-p-Menthane-3-ol;(1S,3S,4R)-p-Menthane-3α-ol;[1S,2R,5S,(+)]-2-Isopropyl-5-methylcyclohexan-1-ol;[1S-(1.alpha.,2.beta.,5.alpha.)]-p-Menthan-3-ol;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S,2R,5S)-;(1S,2R,5S)- | | CAS: | 15356-60-2 | | MF: | C10H20O | | MW: | 156.27 | | EINECS: | 239-387-8 | | Product Categories: | Chiral Reagents;Intermediates & Fine Chemicals;chiral;Biochemistry;for Resolution of Acids;Pharmaceuticals;Monocyclic Monoterpenes;Optical Resolution;Synthetic Organic Chemistry;Terpenes | | Mol File: | 15356-60-2.mol |  |
| | (+)-MENTHOL Chemical Properties |
| Melting point | 43-44 °C (lit.) | | Boiling point | 103-104 °C/9 mmHg (lit.) | | density | 0.890 | | vapor pressure | 0.8 mm Hg ( 20 °C) | | refractive index | 50 ° (C=10, EtOH) | | Fp | 196 °F | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 15.30±0.60(Predicted) | | form | Solid | | color | Colourless to Off-White Oil | | Odor | mentholic | | optical activity | [α]23/D +48°, c = 10 in ethanol | | Water Solubility | Soluble in methanol (almost transparency), chloroform, alcohols, water (456 mg/L at 25°C), and ether. | | BRN | 1902292 | | LogP | 3.15 at 25℃ | | CAS DataBase Reference | 15356-60-2(CAS DataBase Reference) | | EPA Substance Registry System | Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S,2R,5S)- (15356-60-2) |
| Hazard Codes | Xi | | Risk Statements | 37/38-41 | | Safety Statements | 26-39 | | RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | | WGK Germany | 2 | | RTECS | OT0700000 | | TSCA | Yes | | HS Code | 29061100 |
| | (+)-MENTHOL Usage And Synthesis |
| Description | (+)-Menthol is a monoterpene alcohol that has been found in Cannabis and has antifungal activity. It inhibits the growth of F. verticillioides (MIC = 1.5 mM). Unlike (–)-menthol, (+)-menthol does not exhibit analgesia, antibacterial, anticancer, or cholinesterase inhibitory activities. | | Chemical Properties | (+)-MENTHOL is white low melting solid
| | Uses | (1S,2R,5S)-(+)-menthol can undergo acylation with acid anhydrides in the presence of trimethylsilyl trifluoromethanesulfonate to form the corresponding acylated products. | | Uses | (+)-MENTHOL is used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.
| | Definition | ChEBI: (+)-menthol is a p-menthan-3-ol which has (1S,2R,5S)-stereochemistry. In contrast to (-)-menthol, the (+)-enantiomer occurs only rarely in nature. It is an enantiomer of a (-)-menthol. | | General Description | (1S,2R,5S)-(+)-menthol is a chiral secondary alcohol. Its alcohol group can be protected as 2-tetrahydrofuranyl ether by reacting with bromotrichloromethane and tetrahydrofuran. |
| | (+)-MENTHOL Preparation Products And Raw materials |
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