3-Methyl-1-pentyn-3-ol

3-Methyl-1-pentyn-3-ol Basic information
Product Name:3-Methyl-1-pentyn-3-ol
Synonyms:Comesa;Dalgol;Dorison;Dormalest;Dormidin;Dormigen;Dormiphen;Dormison
CAS:77-75-8
MF:C6H10O
MW:98.14
EINECS:201-055-5
Product Categories:Acetylenes;Acetylenic Alcohols & Their Derivatives;Chemistry
Mol File:77-75-8.mol
3-Methyl-1-pentyn-3-ol Structure
3-Methyl-1-pentyn-3-ol Chemical Properties
Melting point -30 °C
Boiling point 121-122 °C(lit.)
density 0.866 g/mL at 25 °C(lit.)
vapor density 3 (vs air)
vapor pressure 6.5 mm Hg ( 20 °C)
refractive index n20/D 1.431(lit.)
Fp 80 °F
storage temp. Flammables area
solubility Cellosolve: miscible
pka13.34±0.29(Predicted)
form clear liquid
color Colorless to Light yellow
explosive limit1.8-16.0%(V)
Merck 13,5870
BRN 969340
CAS DataBase Reference77-75-8(CAS DataBase Reference)
NIST Chemistry ReferenceMeparfynol(77-75-8)
EPA Substance Registry System3-Methyl-1-pentyn-3-ol (77-75-8)
Safety Information
Hazard Codes Xn,F+
Risk Statements 10-22-51/53-2017/10/22
Safety Statements 23-36-61
RIDADR UN 1986 3/PG 3
WGK Germany 1
RTECS SC4900000
HazardClass 3
PackingGroup III
HS Code 29052990
HS Code 29280090
ToxicityLD50 orally in mice, rats, guinea pigs: 600-900 mg/kg (Margolin)
MSDS Information
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3-Methyl-1-pentyn-3-ol Usage And Synthesis
Chemical PropertiesClear slightly yellow liquid or low melting solid
OriginatorCitodorm,Haury
Uses3-Methylpent-1-yn-3-ol is an inhibitor; used in method for preparing high-insulation solvent-free silicone resin for composite insulator.
UsesStabilizer in chlorinated solvents, viscousreducer, electroplating brightener, intermediate insyntheses of hypnotics and isoprenoid chemicals,solvent for polyamide resins, acid inhibitor, preven-tion of hydrogen embrittlement, medicine (soporificand anesthetic).
DefinitionChEBI: Methylpentynol is a ynone.
Manufacturing ProcessTo 5 parts of sodium acetylene in absolute ether 6 parts of dry methyl ethyl ketone was slowly dropwise added with ice cooling and stirring. Than the reaction mixture was poured into excess of acetic acid by ice cooling and extracted with ether. The ether extract was washed with solution of potash for removing the diluted acetic acid and dried over potassium carbonate. The ether was distilled off and residual colorless oil methylpentynol had BP at 120°-121°C. Instead of sodium acetylene the solution of sodium acetylene in liquid ammonia may be successfully used.
Brand nameDormison (Schering).
Therapeutic FunctionSedative
HazardModerate fire risk. Toxic.
3-Methyl-1-pentyn-3-ol Preparation Products And Raw materials
Raw materials2-Butanone
Preparation Products3-AMINO-3-ETHYLBUTYNE-->3-METHYL-1-PENTEN-3-OL-->CIS-3-METHYL-2-PENTENE-->1-Ethynyl-1-methylpropylvalerate-->(E)-3-methylpent-3-en-1-yl acetate
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