DPO-1

DPO-1 Basic information
Product Name:DPO-1
Synonyms:DPO-1;[1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphineoxide;(+)-Neomenthyl diphenylphosphine oxide;(1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]diphenyl-phosphine oxide;DOP-1 (Diphenyl phosphine oxide-1);Phosphine oxide, [(1S,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]diphenyl-;inhibit,DPO1,Inhibitor,DPO 1,Potassium Channel,DPO-1,KcsA
CAS:43077-30-1
MF:C22H29OP
MW:340.44
EINECS:
Product Categories:
Mol File:43077-30-1.mol
DPO-1 Structure
DPO-1 Chemical Properties
storage temp. Store at +4°C
solubility DMSO: soluble2mg/mL, clear (warmed)
form needles
color white
Safety Information
WGK Germany 3
MSDS Information
DPO-1 Usage And Synthesis
DefinitionChEBI: [[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene is a monoterpenoid.
Biological ActivityBlocker of I Kur ultrarapid delayed rectifier potassium current and K V 1.5 channels (IC 50 = 0.31 μ M for rK V 1.5). Displays selectivity for inhibition of I Kur over I to (8-fold), I K1 , I Kr and I Ks (20-fold) in native myocytes and selectivity for rat recombinant K V 1.5 over K V 3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.
storageStore at +4°C
DPO-1 Preparation Products And Raw materials
(S)-(+)-NEOMENTHYLDIPHENYLPHOSPHINE ISOPROPYLDIPHENYLPHOSPHINE OXIDE, 97 DPO-1 DIMETHYLOCTYLPHOSPHINE OXIDE, ANAGRADE? CYCLOHEXYLDIPHENYLPHOSPHINE OXIDE Cyclohexyldiphenylphosphine

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