Dimethyl malonate

Dimethyl malonate Basic information

Product Name:	Dimethyl malonate
Synonyms:	dimthyl malonate;DiMethyl Malonate, 97% 250ML;Malonic Acid Dimethyl Ester Methyl Malonate;DIMETHYL MALONATE FOR SYNTHESIS;Propanedioicacid, 1,3-diMethyl ester;Malonic acid d;Dimethyl malonate Vetec(TM) reagent grade, 98%;PROPANEDIOIC ACID DIMETHYL ESTER
CAS:	108-59-8
MF:	C5H8O4
MW:	132.11
EINECS:	203-597-8
Product Categories:	Thiazoles;Building Blocks;C2 to C5;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;C2 to C5;Carbonyl Compounds;Esters;bc0001;108-59-8
Mol File:	108-59-8.mol

Dimethyl malonate Chemical Properties

Melting point	-62 °C (lit.)
Boiling point	180-181 °C (lit.)
density	1.156 g/mL at 25 °C (lit.)
vapor density	>1 (vs air)
vapor pressure	0.15 hPa (20 °C)
refractive index	n20/D 1.413(lit.)
Fp	194 °F
storage temp.	Store below +30°C.
solubility	alcohol: miscible
pka	11.80±0.46(Predicted)
form	Liquid
color	Clear colorless
Odor	fruity
explosive limit	1.3-17.4%(V)
Water Solubility	negligible
Merck	14,6096
BRN	774261
Stability:	Stable. Incompatible with strong oxidizing agents. Flammable.
InChIKey	BEPAFCGSDWSTEL-UHFFFAOYSA-N
LogP	-0.05 at 20-25℃ and pH6.4
CAS DataBase Reference	108-59-8(CAS DataBase Reference)
NIST Chemistry Reference	Propanedioic acid, dimethyl ester(108-59-8)
EPA Substance Registry System	Dimethyl malonate (108-59-8)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	1
RTECS	OO0950000
Autoignition Temperature	440 °C
Hazard Note	Irritant
TSCA	Yes
HS Code	29171910
Toxicity	LD50 orally in Rabbit: 5331 mg/kg LD50 dermal Rabbit > 5000 mg/kg

MSDS Information

Provider	Language
Methyl malonate	English
SigmaAldrich	English
ACROS	English
ALFA	English

Dimethyl malonate Usage And Synthesis

Description	Dimethyl malonate is a diester derivative of malonic acid. It is a common reagent for organic synthesis used, for example, as a precursor for barbituric acid. It is also used in the malonic ester synthesis. It can be synthesized from dimethoxymethane and carbon monoxide.
Chemical Properties	liquid
Chemical Properties	Dimethyl malonate is soluble in alcohol and ether and very slightly soluble in water. It may slowly decompose.
Uses	It is used in fragrances and some artificial flavorings .
Uses	Dimethyl malonate is a reagent used in organic synthesis. It acts as a precursor for the synthesis of mono-substituted and di-substituted acetic acid, barbiturates, vitamin B1 and vitamin B6. It is used in the pharmaceutical industry to prepare pharmaceuticals like chloroquine and butazolidin. It is involved in the synthesis of diastereomeric pure thienylpyridines by reacting with 1,3-diphenylprop-2-enyl acetate.
Application	Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines. Dimethyl malonate was used in gold catalyzed oxidative esterification of glycerol, 1,2-propanediol and 1,3-propanediol.
Production Methods	Dimethyl malonate is produced via direct esterification of methanol with malonic acid under azeotropic conditions.
General Description	Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines.

Dimethyl malonate Preparation Products And Raw materials

Raw materials

Hydrochloric acid-->Methanol-->Sulfuric acid-->Sodium carbonate-->Sodium cyanide-->Chloroacetic acid-->Sodium chloroacetate-->Cyanoacetic acid-->MALONIC ACID DISODIUM SALT

Preparation Products

1-AMINO-CYCLOPROPANEMETHANOL-->DIMETHYL METHOXYMALONATE-->Chlorimuron-ethyl-->3-(4-FLUOROPHENYL)PROPIONIC ACID-->ADS-->TERT-BUTYL METHYL MALONATE-->2-Methylpyrimidine-->Methyl 3-cyclopentenecarboxylate-->Sethoxydim-->Primisulfuron-methyl-->8-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE-->7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE-->3-CARBETHOXY-4-HYDROXYCOUMARIN-->5-(2-ETHYLTHIO PROPYL)-1,3-CYCLOHEXANEDIONE-->6-Chlorooxindole-->Pipemidic acid-->5-Fluoro-2-oxindole-->DIMETHYL BROMOMALONATE-->7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID METHYL ESTER-->7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID METHYL ESTER-->1,1-Cyclopropanedicarboxylic acid dimethyl ester-->6-CHLORO-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID-->MALONIC ACID DI-N-BUTYL ESTER-->Dimethyl ethylmalonate-->Dimethyl chloromalonate-->5-MESITYL-1,3-CYCLOHEXANEDIONE-->5-(TETRAHYDRO-2H-THIOPYRAN-3-YL)-1,3-CYCLOHEXANEDIONE

Dacthal Dimethyl fluoromalonate N,N-Dimethylformamide Dimethyl malonate Tribenuron methyl Diethyl methylmalonate Dimethyl methylmalonate Dimethyl fumarate Thiophanate-methyl propanedioate Dimethyl disulfide Methyl salicylate Dimethyl isobutylmalonate Dimethyl ether Dimethyl carbonate Methyl acetate Methyl bromide Dimethyl phthalate

Email:[email protected] [email protected]

Dimethyl malonate

Login

Fast registration